10191-43-2 Usage
Description
(2Z)-4-(2,2-dimethylhydrazino)-4-oxobut-2-enoic acid, also known as DMHOA, is a hydrazine derivative characterized by a molecular structure that includes a hydrazino group and a carboxylic acid group. This unsaturated compound features a keto group and a double bond, and while it is not extensively studied, it may hold potential applications across various sectors such as pharmaceuticals, organic synthesis, and catalysis. The specific chemical structure, purity, and formulation of DMHOA can influence its properties and uses, and further research is essential to explore its full potential.
Uses
Used in Pharmaceutical Industry:
DMHOA is utilized as a pharmaceutical intermediate due to its unique molecular structure, which may contribute to the development of new drugs or drug candidates. Its hydrazino and carboxylic acid groups can potentially form key interactions with biological targets, offering a foundation for medicinal chemistry research and drug discovery.
Used in Organic Synthesis:
In the field of organic synthesis, DMHOA serves as a versatile building block for the creation of more complex organic molecules. Its unsaturated nature with a keto group and a double bond allows for various synthetic transformations, making it a valuable component in the synthesis of a wide range of organic compounds.
Used in Catalysis:
DMHOA may also find applications in catalysis, where its hydrazino and carboxylic acid functionalities could be employed to activate substrates or stabilize transition states. This could enhance the efficiency of catalytic processes in various chemical reactions, contributing to the advancement of catalytic technologies.
(Note: The uses listed are speculative based on the general properties of similar compounds and would require experimental validation and research to confirm their applicability and effectiveness.)
Check Digit Verification of cas no
The CAS Registry Mumber 10191-43-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,1,9 and 1 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 10191-43:
(7*1)+(6*0)+(5*1)+(4*9)+(3*1)+(2*4)+(1*3)=62
62 % 10 = 2
So 10191-43-2 is a valid CAS Registry Number.
10191-43-2Relevant articles and documents
Tailoring the substitution pattern of Pyrrolidine-2,5-dione for discovery of new structural template for dual COX/LOX inhibition
Sadiq, Abdul,Mahnashi, Mater H.,Alyami, Bandar A.,Alqahtani, Yahya S.,Alqarni, Ali O.,Rashid, Umer
, (2021/06/15)
Dual inhibition of the enzymatic pathways of cyclooxygenases (COX-1/COX-2) and lipoxygenase (LOX) is a rational approach for developing more efficient and safe anti-inflammatory agents. Herein, dual inhibitors of COX and LOX for the management of inflammation are reported. The structural modifications of starting pyrrolidine-2,5-dione aldehyde derivatives resulted in two structurally diverse families (Family A & B). Synthesized derivatives from both Families displayed preferential COX-2 affinity in submicromolar to nanomolar ranges. Disubstitution pattern of the most active series of compounds having N-(benzyl(4-methoxyphenyl)amino moiety presents a new template that is mimic to the diaryl pattern of traditional COX-2 inhibitors. Compound 78 with IC50 value of 0.051 ± 0.001 μM emerged as the most active compound. Highly potent COX-2/5-LOX inhibitors have also demonstrated appreciable in-vivo anti-inflammatory activity through carrageenan induced paw edema test. Moreover, the involvement of histamine, bradykinin, prostaglandin, and leukotriene mediators to adjust the inflammatory response were also studied. Apart from COX inhibition, sulfonamide is considered an important template for carbonic anhydrase inhibition. Hence, we also evaluated six sulfonamide derivatives for off-target in-vitro bovine carbonic anhydrase-II inhibition. Biological results were finally rationalized by docking simulations. Typically, most active COX-2 inhibitors interact with the amino acid residues responsible for the COX-2 selectivity.
