101969-75-9

Basic information

• Product Name: 2-FLUORO-4'-HYDROXYBENZOPHENONE
• Synonyms: (2-fluorophenyl)(4-hydroxyphenyl)methanone;2-FLUORO-4'-HYDROXYBENZOPHENONE;4-(2-Fluorobenzoyl)phenol
• CAS NO: 101969-75-9
• Molecular Formula: C₁₃H₉FO₂
• Molecular Weight: 216.21
• EINECS: -0
• Mol File: 101969-75-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 115-118°C
• Boiling Point: 392 °C at 760 mmHg
• Flash Point: 190.9 °C
• Appearance: /
• Density: 1.27 g/cm³
• CAS DataBase Reference: 2-FLUORO-4'-HYDROXYBENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-4'-HYDROXYBENZOPHENONE(101969-75-9)
• EPA Substance Registry System: 2-FLUORO-4'-HYDROXYBENZOPHENONE(101969-75-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 101969-75-9(Hazardous Substances Data)

Usage

General Description

2-Fluoro-4'-hydroxybenzophenone is a chemical compound that belongs to the class of benzophenones. It is commonly used as a photoinitiator and UV absorber in various industrial applications, such as inks, coatings, adhesives, and plastics. 2-FLUORO-4'-HYDROXYBENZOPHENONE is known for its ability to efficiently absorb and dissipate UV radiation, making it valuable in protecting materials and products from the damaging effects of ultraviolet light. It is also used in the synthesis of pharmaceuticals and other organic compounds. Additionally, 2-fluoro-4'-hydroxybenzophenone has been studied for its potential environmental impact and toxicity, particularly in aquatic ecosystems.

Upstream product

• 766-49-4 (2-fluorophenyl)acetylene 
• 106-51-4 p-benzoquinone 
• 393-52-2 2-Fluorobenzoyl chloride 
• 100-66-3 methoxybenzene 
• 66938-29-2 (2-fluorophenyl)(4-methoxyphenyl)methanone 

Downstream Products

• 1421854-17-2 1-(4,4-difluoro-1-(4-methoxyphenyl)cyclohexyl)-2-fluorobenzene 
• 1421854-18-3 4-(4,4-difluoro-1-(2-fluorophenyl)cyclohexyl)-2-fluorophenol 
• 460747-42-6 (2-fluorophenyl)(4-hydroxy-3-iodophenyl)methanone 
• 1446099-54-2 (4-(2-chloroethoxy)phenyl)(2-fluorophenyl)methanone 
• 1446099-58-6 (4-(3-chloropropoxy)phenyl)(2-fluorophenyl)methanone 
• 1446099-44-0 (R)-(2-fluorophenyl)(4-(2-(2-methylpyrrolidin-1-yl)ethoxy)phenyl)methanone 
• 1446099-48-4 (R)-(2-fluorophenyl)(4-(3-(2-methylpyrrolidin-1-yl)propoxy)phenyl)methanone 
• 1147713-98-1 (4-(benzyloxy)phenyl)(2-fluorophenyl)methanone 
• 1421854-33-2 4-(2-fluorophenyl)-4-(4-methoxyphenyl)cyclohexanone 
• 1421854-16-1 4-(4,4-difluoro-1-(2-fluorophenyl)cyclohexyl)phenol 
• 1421854-32-1 4-(4-(tert-butyldimethylsilyloxy)phenyl)-4-(2-fluorophenyl)cyclohexanone 
• 1421854-31-0 4-(2-fluorophenyl)-4-(4-hydroxyphenyl)cyclohexanone 

Relevant articles and documents

Visible Light-Mediated [2 + 2] Cycloaddition Reactions of 1,4-Quinones and Terminal Alkynes

A single-step synthesis of 4-hydroxy-functionalized bi-aryl and aryl/alkyl ketones via oxidative coupling of terminal alkynes with benzoquinones is reported. Furthermore, with naphthoquinones, owing to the cross-resonance of carbonyl with the aromatic ring, alkene-alkyne cycloaddition is more favored to give four-membered carbocyclic adducts, thereby precluding the requirement of preactivated alkynes.

4-(2-[2-(2(R)-Methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl)benzonitrile and related 2-aminoethylbenzofuran H3 receptor antagonists potently enhance cognition and attention

H3 receptor antagonists based on a 2-aminoethylbenzofuran skeleton have been discovered, which are potent in vitro at human and rat H 3 receptors, with Ki values of 0.1-5.8 nM. Analogues were discovered with potent (0.01-1 mg/kg) cognition and attention enhancing properties in animal models. One compound in particular, 4-(2-[2-(2(R)- methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl)benzonitrile (ABT-239), combined potent and selective H3 receptor antagonism and excellent pharmacokinetic and metabolic properties across species, with full efficacy in two behavioral models: a five-trial inhibitory avoidance acquisition model in rat pups at 0.1 mg/kg and a social recognition memory model in adult rats at 0.01 mg/kg. Furthermore, this compound did not stimulate locomotor activity and showed high selectivity for the induction of behavioral efficacy versus central nervous system based side effects. The potency and selectivity of this compound and of analogues from this class support the potential of H3 receptor antagonists for the treatment of cognitive dysfunction.