1036273-20-7

Basic information

• Product Name: 2,4,5-trifluorophenylacetic acid methyl ester
• Synonyms: 2,4,5-trifluorophenylacetic acid methyl ester
• CAS NO: 1036273-20-7
• Molecular Weight: 204.149
• Mol File: 1036273-20-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2,4,5-trifluorophenylacetic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,5-trifluorophenylacetic acid methyl ester(1036273-20-7)
• EPA Substance Registry System: 2,4,5-trifluorophenylacetic acid methyl ester(1036273-20-7)

Safety Data

• Hazardous Substances Data: 1036273-20-7(Hazardous Substances Data)

Upstream product

• 327-52-6 1-bromo-2,4,5-trifluorobenzene 
• 96-32-2 bromoacetic acid methyl ester 
• 77-76-9 2,2-dimethoxy-propane 
• 209995-38-0 (2,4,5-trifluorophenyl)acetic acid 
• 1036273-12-7 methyl 2-(2,4,5-trifluorophenyl)-2-chloroacetate 
• 67-56-1 methanol 

Downstream Products

• 209995-38-0 (2,4,5-trifluorophenyl)acetic acid 
• 111991-20-9 2-(2,4,5-trifluorophenyl)acetaldehyde 
• 883267-70-7 2-(2,4,5-trifluorophenyl)ethanol 
• 1476070-53-7 C₁₅H₂₀F₃NO₅S 
• 1476070-52-6 taurine 2-(2,4,5-trifluorophenyl)ethyl ester hydrochloride 
• 1476070-60-6 C₂₃H₂₈F₃N₃O₈S₂ 
• 1476070-57-1 C₂₃H₂₈F₃N₃O₉S 
• 1476070-72-0 N-[(1-β-D-ribofuranosyl-1H-2-thiopyrimidin-5-yl)methyl]-N-trifluoroacetyltaurine 2-(2,4,5-trifluorophenyl)ethyl ester 
• 1476070-69-5 N-[(1-β-D-ribofuranosyl-1H-pyrimidin-5-yl)methyl]-N-trifluoroacetyltaurine 2-(2,4,5-trifluorophenyl)ethyl ester 
• 1476070-66-2 2',3'-O-isopropylidene-N-[(1-β-D-ribofuranosyl-1H-2-thiopyrimidin-5-yl)methyl]-N-trifluoroacetyltaurine2-(2,4,5-trifluorophenyl)ethyl ester 
• 1476070-63-9 2',3'-O-isopropylidene-N-[(1-β-D-ribofuranosyl-1H-pyrimidin-5-yl)methyl]-N-trifluoroacetyltaurine 2-(2,4,5-trifluorophenyl)ethyl ester 
• 1448993-57-4 C₁₈H₂₃F₃O 

Relevant articles and documents

Preparation method of 2, 4, 5-trifluorophenylacetic acid

The invention provides a preparation method of 2, 4, 5-trifluorophenylacetic acid. The method comprises the following steps: 1) reacting 2, 4, 5-trifluorobromobenzene with metal magnesium to obtain 2, 4, 5-trifluorophenyl magnesium bromide; 2) reacting 2, 4, 5-trifluorophenyl magnesium bromide with halogenated acetate to prepare an intermediate A; 3) hydrolyzing the intermediate A in an alkaline solution or an acidic solution to obtain 2, 4, 5-trifluorophenylacetic acid. The structure of the intermediate A is shown as the following structure, wherein R represents a C1-C10 alkyl group. The preparation method of 2, 4, 5-trifluorophenylacetic acid provided by the invention has the advantages of simple process flow, low cost, environmental friendliness and mild conditions.

Stereoselective synthesis of 3,4-di-substituted mercaptolactones via photoredox-catalyzed radical addition of thiophenols

A visible light mediated radical addition of thiophenols on 4-phenylbut-3-enoic acids to give diastereoselective synthesis of 3,4-disubstituted γ-lactones is reported. The reaction precludes the conventional prerequisite of conjugate addition. Furthermore, the lactones were successfully utilized in the synthesis of γ-ketoamides.

PROCESS FOR THE PREPARATION OF FLUOROPHENYLACETIC ACIDS AND DERIVATIVES THEREOF

The object of the present invention is a process for the preparation of fluorophenylacetic acids and derivatives thereof, particularly of 2,4, 5-trifluorophenylacetic acid, starting from the corresponding mandelic acids.