883267-70-7

Basic information

• Product Name: 2-(2,4,5-TRIFLUOROPHENYL)-ETHANOL
• Synonyms: 2-(2,4,5-Trifluorophenyl)ethan;2-(2,4,5-Trifluorophenyl)ethanol, JRD, 97%;2,4,5-trifluoroBenzeneethanol;2,4,5-Trifluorophenethanol
• CAS NO: 883267-70-7
• Molecular Formula: C₈H₇F₃O
• Molecular Weight: 176.14
• EINECS: 200-258-5
• Mol File: 883267-70-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 205.3°C at 760 mmHg
• Flash Point: 88.8°C
• Appearance: /
• Density: 1.33g/cm³
• Vapor Pressure: 0.152mmHg at 25°C
• Refractive Index: 1.4732
• CAS DataBase Reference: 2-(2,4,5-TRIFLUOROPHENYL)-ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,4,5-TRIFLUOROPHENYL)-ETHANOL(883267-70-7)
• EPA Substance Registry System: 2-(2,4,5-TRIFLUOROPHENYL)-ETHANOL(883267-70-7)

Safety Data

• Hazardous Substances Data: 883267-70-7(Hazardous Substances Data)

Usage

General Description

2-(2,4,5-TRIFLUOROPHENYL)-ETHANOL, also known as trifluoromethylphenyl ethanol, is a chemical compound with the molecular formula C8H7F3O. It is a colorless liquid that is commonly used in pharmaceutical and agrochemical manufacturing. 2-(2,4,5-TRIFLUOROPHENYL)-ETHANOL is a derivative of phenethyl alcohol, which is a fragrant alcohol found in various essential oils. The presence of trifluoromethyl and phenyl groups in the compound makes it a valuable building block in the synthesis of various organic and medicinal compounds. Its unique chemical structure and properties make it a versatile intermediate in the production of pharmaceuticals, pesticides, and other organic compounds.

InChI:InChI=1/C8H7F3O/c9-6-4-8(11)7(10)3-5(6)1-2-12/h3-4,12H,1-2H2

Synthetic route

(2,4,5-trifluorophenyl)acetic acid (209995-38-0) → 2-(2,4,5-trifluorophenyl)ethanol (883267-70-7)

Conditions	Yield
With sodium tetrahydroborate; methanesulfonic acid In tetrahydrofuran at -15 - 10℃;	98%
With dimethylsulfide borane complex In diethyl ether; water at 0 - 20℃; for 1h;	93.9%
Stage #1: (2,4,5-trifluorophenyl)acetic acid With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 6h; Stage #2: With water; sodium hydroxide for 18.3333h;	92%
Stage #1: (2,4,5-trifluorophenyl)acetic acid With sulfuric acid In methanol for 3h; Heating; Stage #2: With diisobutylaluminium hydride In tetrahydrofuran; toluene at 20℃; Reagent/catalyst; Temperature; Solvent; Cooling with ice;	90%

2,4,5-trifluorophenylacetic acid methyl ester (1036273-20-7) → 2-(2,4,5-trifluorophenyl)ethanol (883267-70-7)

Conditions	Yield
Stage #1: 2,4,5-trifluorophenylacetic acid methyl ester With sodium tetrahydroborate In tetrahydrofuran at 65℃; for 0.25h; Stage #2: With methanol In tetrahydrofuran for 2.5h; Reflux;	86%

1,2,4-trifluorobenzene (367-23-7) → 2-(2,4,5-trifluorophenyl)ethanol (883267-70-7)

Conditions	Yield
Multi-step reaction with 2 steps 1: aluminum (III) chloride / 6 h / Reflux 2: water; sodium hydroxide / 6 h / 30 °C View Scheme
Multi-step reaction with 2 steps 1: aluminum (III) chloride / 8 h / Reflux 2: water; sodium hydroxide / 3.5 h / 0 °C View Scheme

C8H6ClF3 → 2-(2,4,5-trifluorophenyl)ethanol (883267-70-7)

Conditions	Yield
With water; sodium hydroxide at 30℃; for 6h;

C8H6BrF3 → 2-(2,4,5-trifluorophenyl)ethanol (883267-70-7)

Conditions	Yield
With water; sodium hydroxide at 0℃; for 3.5h;

2-(2,4,5-trifluorophenyl)ethanol (883267-70-7) → 2-(2,4,5-trifluorophenyl)acetaldehyde (111991-20-9)

Conditions	Yield
With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; potassium bromide In dichloromethane; water at 0℃; for 1h;	94%
With manganese(IV) oxide In toluene for 8h; Reagent/catalyst; Solvent; Reflux;	75%

2-(2,4,5-trifluorophenyl)ethanol (883267-70-7) + (R)-2-methylpropane-2-sulfinamide (196929-78-9) → C16H25NOS

Conditions	Yield
With magnesium sulfate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In dichloromethane at -20 - 20℃; for 24h;	93%

2-(2,4,5-trifluorophenyl)ethanol (883267-70-7) + (S)-ethyl 2-(tert-butoxy)-2-(4-(4,4-dimethylpiperidin-1-yl)-5-(4-hydroxyphenyl)-2,6-dimethylpyridin-3-yl)acetate → (S)-2-(tert-butoxy)-2-(4-(4,4-dimethylpiperidin-1-yl)-2,6-dimethyl-5-(4-(2,4,5-trifluorophenethoxy)phenyl)pyridin-3-yl)acetic acid

Conditions	Yield
Stage #1: 2-(2,4,5-trifluorophenyl)ethanol; (S)-ethyl 2-(tert-butoxy)-2-(4-(4,4-dimethylpiperidin-1-yl)-5-(4-hydroxyphenyl)-2,6-dimethylpyridin-3-yl)acetate With di-isopropyl azodicarboxylate In tetrahydrofuran at 20℃; for 18h; Stage #2: With methanol; sodium hydroxide at 75℃; for 16h;	79%

2-(2,4,5-trifluorophenyl)ethanol (883267-70-7) → (2,4,5-trifluorophenyl)acetic acid (209995-38-0)

Conditions	Yield
With manganese(IV) oxide In chloroform for 7h; Reagent/catalyst; Reflux;	79%

2-(2,4,5-trifluorophenyl)ethanol (883267-70-7) + tert-butyl [2-(chlorosulfonyl)ethyl]carbamate (134019-73-1) → C15H20F3NO5S (1476070-53-7)

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 2h;	78%

caffeic acid (331-39-5) + 2-(2,4,5-trifluorophenyl)ethanol (883267-70-7) → 2-(2,4,5-trifluorophenyl)ethyl (E)-3-(3,4-dihydroxyphenyl)acrylate

Conditions	Yield
With ytterbium(III) triflate In nitromethane at 120℃; for 0.666667h;	53.9%

C15H13Cl2NO3 (1173794-90-5) + 2-(2,4,5-trifluorophenyl)ethanol (883267-70-7) → C23H18Cl2F3NO3 (1191248-55-1)

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In diethyl ether at 20℃; Mitsunobu reaction;

2-(2,4,5-trifluorophenyl)ethanol (883267-70-7) + C15H13Cl2NO3 (1285680-62-7) → C23H18Cl2F3NO3

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In diethyl ether at 20℃; Mitsunobu reaction;

2-(2,4,5-trifluorophenyl)ethanol (883267-70-7) → 2',3'-O-isopropylidene-N-[(1-β-D-ribofuranosyl-1H-pyrimidin-5-yl)methyl]-N-trifluoroacetyltaurine 2-(2,4,5-trifluorophenyl)ethyl ester (1476070-63-9)

Conditions	Yield
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 2 h / 0 - 20 °C 2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C 3: triethylamine / 20 °C 4: pyridine / 1 h / 0 °C View Scheme
Multi-step reaction with 5 steps 1: triethylamine / dichloromethane / 2 h / 0 - 20 °C 2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C 3: triethylamine / dichloromethane; N,N-dimethyl-formamide / 20 °C 4: sodium tris(acetoxy)borohydride / 0.67 h / 20 °C 5: pyridine / 1 h / 0 °C View Scheme

2-(2,4,5-trifluorophenyl)ethanol (883267-70-7) → 2',3'-O-isopropylidene-N-[(1-β-D-ribofuranosyl-1H-2-thiopyrimidin-5-yl)methyl]-N-trifluoroacetyltaurine2-(2,4,5-trifluorophenyl)ethyl ester (1476070-66-2)

Conditions	Yield
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 2 h / 0 - 20 °C 2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C 3: triethylamine / 20 °C 4: pyridine / 1 h / 0 °C View Scheme
Multi-step reaction with 5 steps 1: triethylamine / dichloromethane / 2 h / 0 - 20 °C 2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C 3: triethylamine / dichloromethane; N,N-dimethyl-formamide / 20 °C 4: sodium tris(acetoxy)borohydride / 2 h / 20 °C 5: pyridine / 1 h / 0 °C View Scheme

2-(2,4,5-trifluorophenyl)ethanol (883267-70-7) → N-[(1-β-D-ribofuranosyl-1H-pyrimidin-5-yl)methyl]-N-trifluoroacetyltaurine 2-(2,4,5-trifluorophenyl)ethyl ester (1476070-69-5)

Conditions	Yield
Multi-step reaction with 5 steps 1: triethylamine / dichloromethane / 2 h / 0 - 20 °C 2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C 3: triethylamine / 20 °C 4: pyridine / 1 h / 0 °C 5: acetic acid / water / 1 h / 90 °C View Scheme
Multi-step reaction with 6 steps 1: triethylamine / dichloromethane / 2 h / 0 - 20 °C 2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C 3: triethylamine / dichloromethane; N,N-dimethyl-formamide / 20 °C 4: sodium tris(acetoxy)borohydride / 0.67 h / 20 °C 5: pyridine / 1 h / 0 °C 6: acetic acid / water / 1 h / 90 °C View Scheme

2-(2,4,5-trifluorophenyl)ethanol (883267-70-7) → N-[(1-β-D-ribofuranosyl-1H-2-thiopyrimidin-5-yl)methyl]-N-trifluoroacetyltaurine 2-(2,4,5-trifluorophenyl)ethyl ester (1476070-72-0)

Conditions	Yield
Multi-step reaction with 5 steps 1: triethylamine / dichloromethane / 2 h / 0 - 20 °C 2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C 3: triethylamine / 20 °C 4: pyridine / 1 h / 0 °C 5: acetic acid / water / 1 h / 90 °C View Scheme
Multi-step reaction with 6 steps 1: triethylamine / dichloromethane / 2 h / 0 - 20 °C 2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C 3: triethylamine / dichloromethane; N,N-dimethyl-formamide / 20 °C 4: sodium tris(acetoxy)borohydride / 2 h / 20 °C 5: pyridine / 1 h / 0 °C 6: acetic acid / water / 1 h / 90 °C View Scheme

2-(2,4,5-trifluorophenyl)ethanol (883267-70-7) → C23H28F3N3O9S (1476070-57-1)

Conditions	Yield
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 2 h / 0 - 20 °C 2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C 3: triethylamine / 20 °C View Scheme
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 2 h / 0 - 20 °C 2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C 3: triethylamine / dichloromethane; N,N-dimethyl-formamide / 20 °C 4: sodium tris(acetoxy)borohydride / 0.67 h / 20 °C View Scheme

2-(2,4,5-trifluorophenyl)ethanol (883267-70-7) → C23H28F3N3O8S2 (1476070-60-6)

Conditions	Yield
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 2 h / 0 - 20 °C 2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C 3: triethylamine / 20 °C View Scheme
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 2 h / 0 - 20 °C 2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C 3: triethylamine / dichloromethane; N,N-dimethyl-formamide / 20 °C 4: sodium tris(acetoxy)borohydride / 2 h / 20 °C View Scheme

2-(2,4,5-trifluorophenyl)ethanol (883267-70-7) → C23H26F3N3O9S

Conditions	Yield
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 2 h / 0 - 20 °C 2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C 3: triethylamine / dichloromethane; N,N-dimethyl-formamide / 20 °C View Scheme

2-(2,4,5-trifluorophenyl)ethanol (883267-70-7) → C23H26F3N3O8S2

Conditions	Yield
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 2 h / 0 - 20 °C 2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C 3: triethylamine / dichloromethane; N,N-dimethyl-formamide / 20 °C View Scheme

2-(2,4,5-trifluorophenyl)ethanol (883267-70-7) → taurine 2-(2,4,5-trifluorophenyl)ethyl ester hydrochloride (1476070-52-6)

Conditions	Yield
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 2 h / 0 - 20 °C 2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C View Scheme

2-(2,4,5-trifluorophenyl)ethanol (883267-70-7) → C27H28F3NO2

Conditions	Yield
Multi-step reaction with 3 steps 1.1: manganese(IV) oxide / toluene / 8 h / Reflux 2.1: tetrahydrofuran / 12 h / Reflux 3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -20 °C 3.2: 2 h / -20 °C View Scheme

2-(2,4,5-trifluorophenyl)ethanol (883267-70-7) → (R,R)-N-benzyl-N-(α-methylbenzyl)-1-(2',4',5'-trifluorophenyl)-4-oxo-4-{3''-(trifluoromethyl)-5'',6''-dihydro-1'',2'',4''-triazolo[4,3-α]pyrazin-7''(8''H)-yl}butan-2-amine (1380521-88-9)

Conditions	Yield
Multi-step reaction with 4 steps 1.1: manganese(IV) oxide / toluene / 8 h / Reflux 2.1: tetrahydrofuran / 12 h / Reflux 3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -20 °C 3.2: 2 h / -20 °C 4.1: hydrogenchloride / water / 12 h / Reflux 4.2: 0.5 h / Cooling with ice 4.3: 20 °C View Scheme

2-(2,4,5-trifluorophenyl)ethanol (883267-70-7) → sitagliptin (486460-32-6)

Conditions	Yield
Multi-step reaction with 5 steps 1.1: manganese(IV) oxide / toluene / 8 h / Reflux 2.1: tetrahydrofuran / 12 h / Reflux 3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -20 °C 3.2: 2 h / -20 °C 4.1: hydrogenchloride / water / 12 h / Reflux 4.2: 0.5 h / Cooling with ice 4.3: 20 °C 5.1: hydrogen; 5%-palladium/activated carbon; acetic acid / methanol / 48 h / 50 °C / 19001.3 Torr View Scheme
Multi-step reaction with 6 steps 1.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; magnesium sulfate / dichloromethane / 24 h / -20 - 20 °C 2.1: sodium hydrogencarbonate / 120 h / -30 - 20 °C 3.1: hydrogenchloride / water / 50 - 115 °C 4.1: sodium hydroxide / tetrahydrofuran; water / 1 h / 0 °C 4.2: 20 °C 5.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; 1,2-dichloro-ethane / N,N-dimethyl-formamide / -15 - 20 °C 6.1: hydrogenchloride / water; methanol / 20 °C View Scheme
Multi-step reaction with 6 steps 1.1: potassium bromide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite; sodium hydrogencarbonate / water; dichloromethane / 1 h / 0 °C 2.1: pyridinium p-toluenesulfonate; magnesium sulfate / dichloromethane / 4 h / 20 °C 3.1: potassium carbonate; sodium iodide / 4 h / 20 °C 4.1: hydrogenchloride / water / 9 h / Reflux 4.2: 20 °C 5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / N,N-dimethyl-formamide / 4 h / -5 - 20 °C 6.1: methanol; hydrogenchloride / water / 4 h / 50 °C View Scheme

2-(2,4,5-trifluorophenyl)ethanol (883267-70-7) → sitagliptin phosphate

Conditions

Yield

Multi-step reaction with 6 steps 1.1: manganese(IV) oxide / toluene / 8 h / Reflux 2.1: tetrahydrofuran / 12 h / Reflux 3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -20 °C 3.2: 2 h / -20 °C 4.1: hydrogenchloride / water / 12 h / Reflux 4.2: 0.5 h / Cooling with ice 4.3: 20 °C 5.1: hydrogen; 5%-palladium/activated carbon; acetic acid / methanol / 48 h / 50 °C / 19001.3 Torr 6.1: phosphoric acid / ethanol / 0.5 h / Reflux View Scheme

2-(2,4,5-trifluorophenyl)ethanol (883267-70-7) → (E)-4-(2,4,5-trifluorophenyl)but-2-enoic acid ethyl ester

Conditions	Yield
Multi-step reaction with 2 steps 1: manganese(IV) oxide / toluene / 8 h / Reflux 2: tetrahydrofuran / 12 h / Reflux View Scheme

2-(2,4,5-trifluorophenyl)ethanol (883267-70-7) → C17H22F3NO5S

Conditions	Yield
Multi-step reaction with 2 steps 1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; magnesium sulfate / dichloromethane / 24 h / -20 - 20 °C 2: sodium hydrogencarbonate / 120 h / -30 - 20 °C View Scheme

2-(2,4,5-trifluorophenyl)ethanol (883267-70-7) → (R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester (881995-69-3)

Conditions	Yield
Multi-step reaction with 3 steps 1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; magnesium sulfate / dichloromethane / 24 h / -20 - 20 °C 2: sodium hydrogencarbonate / 120 h / -30 - 20 °C 3: hydrogenchloride / water / 50 - 115 °C View Scheme

2-(2,4,5-trifluorophenyl)ethanol (883267-70-7) → 3-(R)-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester (881995-73-9)

Conditions	Yield
Multi-step reaction with 4 steps 1.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; magnesium sulfate / dichloromethane / 24 h / -20 - 20 °C 2.1: sodium hydrogencarbonate / 120 h / -30 - 20 °C 3.1: hydrogenchloride / water / 50 - 115 °C 4.1: sodium hydroxide / tetrahydrofuran; water / 1 h / 0 °C 4.2: 20 °C View Scheme

Upstream product

• 367-23-7 1,2,4-trifluorobenzene 
• 209995-38-0 (2,4,5-trifluorophenyl)acetic acid 
• 1036273-20-7 2,4,5-trifluorophenylacetic acid methyl ester 

Downstream Products

• 1191248-55-1 C₂₃H₁₈Cl₂F₃NO₃ 
• 1476070-53-7 C₁₅H₂₀F₃NO₅S 
• 1476070-60-6 C₂₃H₂₈F₃N₃O₈S₂ 
• 1476070-52-6 taurine 2-(2,4,5-trifluorophenyl)ethyl ester hydrochloride 
• 1380521-88-9 (R,R)-N-benzyl-N-(α-methylbenzyl)-1-(2',4',5'-trifluorophenyl)-4-oxo-4-{3''-(trifluoromethyl)-5'',6''-dihydro-1'',2'',4''-triazolo[4,3-α]pyrazin-7''(8''H)-yl}butan-2-amine 
• 486460-32-6 sitagliptin 
• 654671-78-0 sitagliptin phosphate 
• 111991-20-9 2-(2,4,5-trifluorophenyl)acetaldehyde 
• 209995-38-0 (2,4,5-trifluorophenyl)acetic acid 
• 881995-69-3 (R)-3-amino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester 
• 881995-73-9 3-(R)-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)butyric acid methyl ester 
• 486460-23-5 (R)-tert-butyl 4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate 
• 1349649-83-7 (R)-2-methyl-N-((R)-4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4] triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)propane-2-sulfinamide 
• 486460-00-8 (3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid 

Relevant articles and documents

Novel method for preparing 2,4,5-trifluoro phenylacetic acid

The invention provides a novel method for preparing 2,4,5-trifluoro-phenylacetic acid. The novel method specifically comprises the following steps: (1) dissolving 1,2,4-trifluoro benzene into 1,2-dihalogenated ethane, carrying out a Friedel-crafts alkylation reaction under catalysis of a lewis acid catalyst, thus preparing 2,4,5-trifluoro halogenated ethylbenzene; (2) hydrolyzing the 2,4,5-trifluoro halogenated ethylbenzene obtained in the step (1) in an alkaline system, thus obtaining 2,4,5-trifluoro phenethyl alcohol; (3) oxidizing the 2,4,5-trifluoro phenethyl alcohol obtained in the step (2), thus obtaining the 2,4,5-trifluoro phenylacetic acid. The novel method disclosed by the invention has the advantages that raw materials are easy to obtain, the reaction is mild, the operation is easy, the cost is low, environment friendliness is realized, no high-toxicity reagent exists, and the like.

A west he row sandbank and its salt synthesis method (by machine translation)

The invention discloses a west he row sandbank and its salt synthesis method, in order to 2, 4, 5 - trifluorobenzene acetic acid as the starting material, through esterification, reduction, oxidation and Witting reaction, to obtain 4 - (2, 4, 5 - trifluorophenyl) - 2 - butene ethyl ester, or passes through the reduction, oxidation and Witting reaction after, to obtain 4 - (2, 4, 5 - trifluorophenyl) - 2 - butene ethyl ester. Then in BuLi or six methyl two silicon and nitrogen under the action of the alkane-sodium, with chiral amine on the hydroamination reaction, framed asymmetric amination product, through ester, condensation, hydrogenated three-step reaction to obtain sitagliptin. The west he of the spit of fland synthesis method of raw materials are cheap and easy to obtain, steps are less, the operation is easy, can be effectively reduced. The method can be the high purity of the sitagliptin, the salt of the phosphoric acid obtained after HPLC purity and sitagliptin ee values are in 99% or more, can be applied to the medical field. (by machine translation)

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