109417-72-3Relevant articles and documents
Aldol condensations catalysed by novel Mg-Al-O-t-Bu hydrotalcite
Choudary,Lakshmi Kantam,Kavita,Venkat Reddy,Koteswara Rao,Figueras
, p. 3555 - 3558 (1998)
A novel Mg-AI-O-t-Bu hyckotalcite prepared for the first time, catalyses condensation reactions selectively to aldols (3) at 0°C in quantitative yields.
A photoswitchable organocatalyst based on a catalyst-imprinted polymer containing azobenzene
Liu, Hua-Dong,Zheng, An-Xun,Gong, Cheng-Bin,Ma, Xue-Bing,Hon-Wah Lam, Michael,Chow, Cheuk-Fai,Tang, Qian
, p. 62539 - 62542 (2015)
An l-proline-catalyzed aldol reaction was photo-controlled using an l-proline-imprinted polymer containing azobenzene. Upon UV irradiation, azobenzene chromophores underwent trans → cis isomerization, thereby releasing l-proline to catalyze the aldol reac
A Mild Procedure for Enone Preparation Catalysed by Bovine Serum Albumin in a Green and Easily Available Medium
Ardanaz, Sebastián M.,Velez Rueda, Ana J.,Parisi, Gustavo,Iribarren, Adolfo M.,Iglesias, Luis E.
, p. 1750 - 1757 (2018)
Abstract: A simple and mild procedure to obtain α,β-unsaturated ketones from acetone and a set of benzaldehydes is described. The approach applies bovine serum albumin (BSA) catalysis and water or ethanol, this mild reaction medium contrasting with the strong reaction conditions of the classic aldol condensation. Except for the assayed nitrobenzaldehydes, high enone yields (88–97%) were attained. In addition to its mildness, further advantages of this procedure are the use of a green catalyst exhibiting an efficient reuse and the use of eco-friendly and cheap solvents. In order to gain a deeper understanding of the involved catalytic mechanism, computational experiments on BSA structural analysis and molecular docking were carried out.
Controlled construction of metal-organic frameworks: Hydrothermal synthesis, X-ray structure, and heterogeneous catalytic study
Sen, Rupam,Saha, Debraj,Koner, Subratanath
, p. 5979 - 5986 (2012)
The role of pH in the formation of metal-organic frameworks (MOFs) has been studied for a series of magnesium-based carboxylate framework systems. Our investigations have revealed the formation of five different zero-dimensional (0D) to three-dimensional (3D) ordered frameworks from the same reaction mixture, merely by varying the pH of the medium. The compounds were synthesized by the hydrothermal method and characterized by single-crystal X-ray diffraction. Increase of the pH of the medium led to abstraction of the imine hydrogen from the ligand and a concomitant increase in the OH- ion concentration in the solution, facilitating the construction of higher dimensional framework compounds. A stepwise increase in pH resulted in a stepwise increase in the dimensionality of the network, ultimately leading to the formation of a 3D porous solid. A gas adsorption study of the 3D framework compound confirmed its microporosity with a BET surface area of approximately 450 m2 g-1. Notably, the 3D framework compound catalyzes aldol condensation reactions of various aromatic aldehydes with acetone under heterogeneous conditions. Copyright
Cyclodextrin-based class I aldolase enzyme mimics to catalyze crossed aldol condensations
Yuan, De-Qi,Dong, Steven D.,Breslow, Ronald
, p. 7673 - 7676 (1998)
A variety of mono- and unsymmetrical bifunctional β-cyclodextrins have been developed as efficient mimics of class I aldolases, some of which show a large rate acceleration and substrate selectivity.
PH-Tuned modulation of 1d chain to 3d metal-organic framework: Synthesis, structure and their useful application in the heterogeneous claisen-Schmidt reaction
Sen, Rupam,Saha, Debraj,Koner, Subratanath,Mal, Dasarath,Brando, Paula,Lin, Zhi
, p. 591 - 598 (2015)
The role of pH in the formation of metal-organic frameworks (MOFs) has been studied on magnesium-based carboxylate framework systems [Mg(Pdc)(H2O)3]n (1) and [Mg(Pdc)(H2O)]n (2) (Pdc=pyridine-2,3-dica
Direct aldol and tandem Mannich reactions in room temperature ammonia solutions
Feng, Lichun,Xu, Lijin,Lam, Kimhung,Zhou, Zhongyuan,Yip,Chan, Albert S.C.
, p. 8685 - 8689 (2005)
An economical, simple, and efficient direct aldol reaction via the double activation of both aldehydes and ketones by ammonia has been developed. An unprecedented tandem Mannich reaction was observed when hydroxybenzaldehydes, pyrrole-2-carboxyaldehyde, a
MnO2as a terminal oxidant in Wacker oxidation of homoallyl alcohols and terminal olefins
Fernandes, Rodney A.,Ramakrishna, Gujjula V.,Bethi, Venkati
, p. 6115 - 6125 (2020/10/27)
Efficient and mild reaction conditions for Wacker-type oxidation of terminal olefins of less explored homoallyl alcohols to β-hydroxy-methyl ketones have been developed by using a Pd(ii) catalyst and MnO2 as a co-oxidant. The method involves mild reaction conditions and shows good functional group compatibility along with high regio- and chemoselectivity. While our earlier system of PdCl2/CrO3/HCl produced α,β-unsaturated ketones from homoallyl alcohols, the present method provided orthogonally the β-hydroxy-methyl ketones. No overoxidation or elimination of benzylic and/or β-hydroxy groups was observed. The method could be extended to the oxidation of simple terminal olefins as well, to methyl ketones, displaying its versatility. An application to the regioselective synthesis of gingerol is demonstrated.
Traceless OH-Directed Wacker Oxidation-Elimination, an Alternative to Wittig Olefination/Aldol Condensation: One-Pot Synthesis of α,β-Unsaturated and Nonconjugated Ketones from Homoallyl Alcohols
Bethi, Venkati,Fernandes, Rodney A.
, p. 8577 - 8584 (2016/09/28)
A new method for one-pot synthesis of β-substituted and β,β-disubstituted α,β-unsaturated methyl ketones from homoallyl alcohols by sequential PdCl2/CrO3-promoted Wacker process followed by an acid-mediated dehydration reaction has been developed. Remarkably, internal homoallyl alcohols delivered regioselectively nonconjugated unsaturated carbonyl compounds under the same protocol. A new starting material-based synthesis of α,β-unsaturated and nonconjugated methyl ketones is demonstrated.
