1097211-38-5

Basic information

• Product Name: (1R)-2-bromo-1-(4-fluorophenyl)ethan-1-ol
• Synonyms: (1R)-2-bromo-1-(4-fluorophenyl)ethan-1-ol
• CAS NO: 1097211-38-5
• Molecular Weight: 219.053
• Mol File: 1097211-38-5.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: (1R)-2-bromo-1-(4-fluorophenyl)ethan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (1R)-2-bromo-1-(4-fluorophenyl)ethan-1-ol(1097211-38-5)
• EPA Substance Registry System: (1R)-2-bromo-1-(4-fluorophenyl)ethan-1-ol(1097211-38-5)

Safety Data

• Hazardous Substances Data: 1097211-38-5(Hazardous Substances Data)

Upstream product

• 403-29-2 2-bromo-4'-fluoroacetophenone 
• 332-42-3 (2-bromoethyl)-4-fluorobenzene 
• 7589-27-7 2-(4-Fluorophenyl)ethanol 
• 405-99-2 para-fluorostyrene 
• 95895-33-3 1-(bromoethynyl)-4-fluorobenzene 

Relevant articles and documents

Cascade bio-hydroxylation and dehalogenation for one-pot enantioselective synthesis of optically active β-halohydrins from halohydrocarbons

A stereoselective hydroxylation and enantioselective dehalogenation cascade reaction was developed for the synthesis of optically active β-haloalcohols from halohydrocarbons. This cascade system employed P450 and halohydrin dehalogenase as two compatible biocatalysts, allowing a straightforward, greener and efficient access to β-halohydrins with excellent enantioselectivities (98-99%).

Integration of multiple active sites on large-pore mesoporous silica for enantioselective tandem reactions

Facile construction of a multifunctional heterogeneous catalyst through the assembly of Au/carbene and chiral ruthenium/diamine dual complexes in large-pore mesoporous silica was developed. This enables an efficient one-pot hydration-asymmetric transfer hydrogenation enantioselective tandem reaction of haloalkynes, affording chiral halohydrins with up to 99% enantioselectivity. Combined multifunctionalities, such as substrate-promoted silanol-functionality, BF4? anion-bonding gold/carbene and covalent-bonding chiral ruthenium/diamine active centers, contributed cooperatively to the catalytic performance.

Catalytic Asymmetric Bromination of Unfunctionalized Olefins with H2O as a Nucleophile

The dimeric cinchona alkaloid (DHQD)2PHAL is used to catalyze an effective asymmetric bromohydroxylation of unfunctionalized olefins with H2O as nucleophile an N-bromobenzamide as a bromine source. A variety of optically active bromohydrins are formed with up to 88%ee. PHAL's positive: An effective asymmetric bromohydroxylation of unfunctionalized olefins with H2O as nucleophile catalyzed by the dimeric cinchona alkaloid (DHQD)2PHAL (see scheme) is described. Optically active bromohydrins are obtained with up to 88%ee.