1100676-16-1

Basic information

• Product Name: AtracuriuM IMpurity D2 (cis-Quaternary Alcohol)
• Synonyms: AtracuriuM IMpurity D2 (cis-Quaternary Alcohol)
• CAS NO: 1100676-16-1
• Molecular Weight: 673.825
• Mol File: 1100676-16-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: AtracuriuM IMpurity D2 (cis-Quaternary Alcohol)(CAS DataBase Reference)
• NIST Chemistry Reference: AtracuriuM IMpurity D2 (cis-Quaternary Alcohol)(1100676-16-1)
• EPA Substance Registry System: AtracuriuM IMpurity D2 (cis-Quaternary Alcohol)(1100676-16-1)

Safety Data

• Hazardous Substances Data: 1100676-16-1(Hazardous Substances Data)

Upstream product

• 111-29-5 1 ,5-pentanediol 
• 1100676-20-7 C₆H₅O₃S^(1-)*C₂₄H₃₁ClNO₅⁽¹⁺⁾ 
• 1075727-06-8 (1R,2R)-2-(2-carboxyethyl)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolinium besylate 
• 98-11-3 benzenesulfonic acid 
• 1075727-00-2 (1R-cis)-1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-2-tert-butoxycarbonylethyl-isoquinolinium besylate 

Relevant articles and documents

PROCESS FOR PRODUCING CISATRACURIUM AND ASSOCIATED INTERMEDIATES

The present invention provides a process of producing cisatracurium compounds, e.g., cisatracurium besylate, from isoquinolinium salts of the structural formula (VIIA) wherein X- is an anion and R is H or a C1-C6 alkyl, or an activated form of the carboxylic acid with 1,5-pentanediol to form a cisatracurium salt, optionally via an intermediate compound (VIII). The cisatracurium compounds can be purified using simple techniques to afford pure cisatracurium besylate without the need for HPLC purification.