112424-29-0

Basic information

• Product Name: 1H-Isoindole-1,3(2H)-dione, 2-(2-phenylpropyl)-, (R)-
• CAS NO: 112424-29-0
• Molecular Formula: C17H15NO2
• Molecular Weight: 265.312
• Mol File: 112424-29-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1H-Isoindole-1,3(2H)-dione, 2-(2-phenylpropyl)-, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindole-1,3(2H)-dione, 2-(2-phenylpropyl)-, (R)-(112424-29-0)
• EPA Substance Registry System: 1H-Isoindole-1,3(2H)-dione, 2-(2-phenylpropyl)-, (R)-(112424-29-0)

Safety Data

• Hazardous Substances Data: 112424-29-0(Hazardous Substances Data)

Usage

Enantiomer

1H-isoindole-1,3(2H)-dione, 2-(2-phenylpropyl)-, (S)-

Derivative

isoindole-1,3-dione

Uses

synthesis of pharmaceutical compounds and agrochemicals

Biological activities

potential antitumor and anti-inflammatory properties

Importance of stereochemistry

crucial role in determining biological and pharmacological activities.

Upstream product

• 3360-54-1 3-bromo-2-phenylprop-1-ene 
• 98-83-9 isopropenylbenzene 
• 98-86-2 acetophenone 
• 16307-59-8 N-(2-phenyl-2-propenyl)phthalimide 
• 20780-53-4 (R)-Styrene oxide 
• 1123-85-9 (+)-(R)-2-phenylpropanol 
• 112424-28-9 (S)-1-Phthalimido-2-(trifluormethylsulfonyloxy)propane 
• 71-43-2 benzene 
• 112424-27-8 (R)-1-Phthalimido-2-(trifluormethylsulfonyloxy)propane 
• 136918-14-4 phthalimide 
• 1972-28-7 diethylazodicarboxylate 

Downstream Products

• 1445-69-8 2,3-dihydrophthalazine-1,4-dione 
• 582-22-9 (R)-2-phenylpropylamine 
• 375345-95-2 {(2R)-2-[4-(4-{2-[(methylsulfonyl)amino]ethyl}phenyl)phenyl]-propyl}[(methylethyl)sulfonyl]amine 
• 375345-98-5 propane-2-sulfonic acid (2-(4-iodophenyl)propyl)amide 
• 375345-97-4 propane-2-sulfonic acid (2-phenylpropyl)amide 

Relevant articles and documents

Highly Enantioselective Iridium-Catalyzed Hydrogenation of 2-Aryl Allyl Phthalimides

The iridium-catalyzed asymmetric hydrogenation of 2-aryl allyl phthalimides to afford enantioenriched β-aryl-β-methyl amines is presented. Recently developed Ir-MaxPHOX catalysts are used for this enantioselective transformation. The mild reaction conditions and the feasible removal of the phthalimido group makes this catalytic method easily scalable and of great interest to afford chiral amines. The importance of this new methodology is exemplified by the formal synthesis of (R)-Lorcaserin, OTS514, and enantiomerically enriched 3-methyl indolines.

Combination therapy for treatment of depression

The present invention provides a method for treating depression, comprising administering to a patient an effective amount of a first component which is a suitable antidepressant, in combination with an effective amount of a second component which is a suitable AMPA receptor potentiator.