375345-98-5

Basic information

• Product Name: propane-2-sulfonic acid (2-(4-iodophenyl)propyl)amide
• Synonyms: propane-2-sulfonic acid (2-(4-iodophenyl)propyl)amide
• CAS NO: 375345-98-5
• Molecular Weight: 367.251
• Mol File: 375345-98-5.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: propane-2-sulfonic acid (2-(4-iodophenyl)propyl)amide(CAS DataBase Reference)
• NIST Chemistry Reference: propane-2-sulfonic acid (2-(4-iodophenyl)propyl)amide(375345-98-5)
• EPA Substance Registry System: propane-2-sulfonic acid (2-(4-iodophenyl)propyl)amide(375345-98-5)

Safety Data

• Hazardous Substances Data: 375345-98-5(Hazardous Substances Data)

Upstream product

• 34298-25-4 (R)-β-methylphenethylamine hydrochloride 
• 375345-97-4 propane-2-sulfonic acid (2-phenylpropyl)amide 
• 1823-91-2 1-phenylethyl cyanide 
• 20780-53-4 (R)-Styrene oxide 
• 112424-29-0 (R)-2-(2-phenylpropyl)isoindoline-1,3-dione 
• 582-22-9 (R)-2-phenylpropylamine 
• 1123-85-9 (+)-(R)-2-phenylpropanol 
• 685876-10-2 (2R)-2-phenylpropylamine Malate 

Downstream Products

• 375345-95-2 {(2R)-2-[4-(4-{2-[(methylsulfonyl)amino]ethyl}phenyl)phenyl]-propyl}[(methylethyl)sulfonyl]amine 
• 516491-32-0 N,N'-([1,1'-biphenyl]-4,4'-diyldi-2,1-ethanediyl)-bis-methanesulfonamide 
• 7440-05-3 palladium 

Relevant articles and documents

Enantioselective Synthesis of β-Methyl Amines via Iridium-Catalyzed Asymmetric Hydrogenation of N-Sulfonyl Allyl Amines

The iridium-catalyzed asymmetric hydrogenation of several N-sulfonyl allyl amines is reported. All substrates can be easily obtained by the Ir-catalyzed isomerization of N-tosylaziridines reported previously. The commercially available threonine-derived phosphinite (UbaPHOX) iridium complex has been found to be the best catalyst for this catalytic application, affording β-methyl amines with good to excellent ee values (up to 94%). The synthetic potential of this novel methodology was demonstrated by the formal synthesis of Lorcaserin and LY-404187. (Figure presented.).

Structure based evolution of a novel series of positive modulators of the AMPA receptor

Starting from compound 1, we utilized biostructural data to successfully evolve an existing series into a new chemotype with a promising overall profile, exemplified by 19.

Sulfonamide derivatives

The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof which is useful for the treatment of conditions associated with glutamate hypofunction, such as psychiatric and neurological disorders.