1160246-89-8

Basic information

• Product Name: 1-Oxa-7-azaspiro[4.5]decane-7-carboxylic acid, 3-oxo-, 1,1-diMethylethyl ester
• Synonyms: 1-Oxa-7-azaspiro[4.5]decane-7-carboxylic acid, 3-oxo-, 1,1-diMethylethyl ester;tert-butyl 3-oxo-1-oxa-7-azaspiro[4.5]decane-7-carboxylate
• CAS NO: 1160246-89-8
• Molecular Formula: C13H21NO4
• Molecular Weight: 255.31014
• Mol File: 1160246-89-8.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Oxa-7-azaspiro[4.5]decane-7-carboxylic acid, 3-oxo-, 1,1-diMethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Oxa-7-azaspiro[4.5]decane-7-carboxylic acid, 3-oxo-, 1,1-diMethylethyl ester(1160246-89-8)
• EPA Substance Registry System: 1-Oxa-7-azaspiro[4.5]decane-7-carboxylic acid, 3-oxo-, 1,1-diMethylethyl ester(1160246-89-8)

Safety Data

• Hazardous Substances Data: 1160246-89-8(Hazardous Substances Data)

Usage

Molecular weight

414.48 g/mol

Functional group

1,1-diMethylethyl ester group, which enhances stability and lipophilicity.

Medication use

Treats high blood pressure and congestive heart failure.

Mechanism of action

Blocks the action of certain natural substances (e.g., epinephrine) on the heart and blood vessels, leading to lower blood pressure, improved heart function, and reduced strain on the heart.

Upstream product

• 1429121-55-0 tert-butyl 3-hydroxy-3-[3-(trimethylsilyl)prop-2-yn-1-yl]piperidine-1-carboxylate 
• 98977-36-7 3-oxo-piperidine-1-carboxylic acid tert-butyl ester 
• 1429121-56-1 tert-butyl 3-hydroxy-3-(prop-2-yn-1-yl)piperidine-1-carboxylate 

Downstream Products

• 1429122-62-2 tert-butyl 3-phenyl-1-oxa-7-azaspiro[4.5]dec-2-ene-7-carboxylate 
• 1429122-63-3 (4-chlorophenyl)(3-phenyl-1-oxa-7-azaspiro[4.5]dec-2-en-7-yl)methanone 

Relevant articles and documents

Skeletal diversification via heteroatom linkage control: Preparation of bicyclic and spirocyclic scaffolds from N-substituted homopropargyl alcohols

The discovery and application of a new branching pathway synthesis strategy that rapidly produces skeletally diverse scaffolds is described. Two different scaffold types, one a bicyclic iodo-vinylidene tertiary amine/tertiary alcohol and the other, a spirocyclic 3-furanone, are each obtained using a two-step sequence featuring a common first step. Both scaffold types lead to intermediates that can be orthogonally diversified using the same final components. One of the scaffold types was obtained in sufficiently high yield that it was immediately used to produce a 97-compound library.