1174681-30-1

Basic information

• Product Name: (2R)-3-(3,4-dihydroxyphenyl)-2-hydroxypropanoic acid (S)-PGME amide
• Synonyms: (2R)-3-(3,4-dihydroxyphenyl)-2-hydroxypropanoic acid (S)-PGME amide
• CAS NO: 1174681-30-1
• Molecular Weight: 345.352
• Mol File: 1174681-30-1.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: (2R)-3-(3,4-dihydroxyphenyl)-2-hydroxypropanoic acid (S)-PGME amide(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-3-(3,4-dihydroxyphenyl)-2-hydroxypropanoic acid (S)-PGME amide(1174681-30-1)
• EPA Substance Registry System: (2R)-3-(3,4-dihydroxyphenyl)-2-hydroxypropanoic acid (S)-PGME amide(1174681-30-1)

Safety Data

• Hazardous Substances Data: 1174681-30-1(Hazardous Substances Data)

Upstream product

• 115939-25-8 salvianolic acid B 
• 1393828-22-2 shimobashiric acid C 
• 865999-05-9 shimobashiric acid B 
• 20283-92-5 (R)-(+)-rosmarinic acid 
• 6591-61-3 (S)-Phenylglycine methyl ester 
• 23028-17-3 danshensu 

Relevant articles and documents

Hyaluronidase inhibitory rosmarinic acid derivatives from Meehania urticifolia

Nine new phenylpropanoids, rashomonic acids A-D (1-4) and meehaniosides A-E (5-9), along with four known compounds were isolated from Meehania urticifolia. The structure of each new compound was elucidated based on the results of spectroscopic analyses. Compounds 3-8 showed moderate hyaluronidase inhibitory activity with IC50 values of 183-1049 μM.

Hyaluronidase inhibitors from Takuran, Lycopus lucidus

Takuran is a traditional herbal medicine that is produced from the herbal plant Lycopus lucidas TURCZ. (Lamiaceae). Takuran is used as a treatment for diseases in women. From Takuran, four new phenylpropanoids along with 18 known compounds were isolated, and their structures were elucidated by spectroscopic analyses. Five phenylpropanoids isolated from the plant showed hyaluronidase inhibitory activity comparable to that of rosmarinic acid.

New Benzofuran Lignans from Nepeta multifida

The new benzofuran lignans nepetamultin A (1) and B (2) were isolated from flowers of Nepeta multifida L. [Schizonepeta multifida (L.) Briq.; Lamiaceae]. UV and NMR spectroscopic and mass spectrometric data indicated 1 was the 9′9′′′-di-O-methyl ester of schizotenuin A; 2, the 9′-O-methyl ester of schizotenuin C1. Biological studies revealed that 1 and 2 possessed antioxidant and antihyaluronidase activity.

Diastereomers of lithospermic acid and lithospermic acid B from Monarda fistulosa and Lithospermum erythrorhizon

Monardic acids A (1) and B (2), which are (7R,8R) diastereomers of lithospermic acid (LA) and lithospermic acid B, respectively, were isolated from Monarda fistulosa. A (7S,8R) isomer (3) of LA was also isolated from this plant, and a (7R,8S) isomer (7) of LA was obtained from Lithospermum erythrorhizon. The absolute configuration of 1 was confirmed by analysis of its hydrolysates, 7-epiblechnic acid and 2R-3-(3,4-dihydroxyphenyl)-2- hydroxypropanoic acid. The configuration in the dihydrobenzofuran moieties of 2, 3, and 7 was extrapolated by using the phenylglycine methyl ester method and a Cotton effect at approximately 250-260 nm in their electronic circular dichroism spectra. Diastereomers (1-3 and 7) displayed moderate hyaluronidase inhibitory and histamine release inhibitory activities.