118171-02-1Relevant articles and documents
MACROCYCLIC COMPOUNDS
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Paragraph 0139, (2020/09/27)
Disclosed are macrocyclic compounds of formula (I) comprising a 2-carboxy indole ring. Such compounds, and their pharmaceutically acceptable salts, are useful as Mcl-1 (myeloid cell leukemia-1) inhibitors. The compounds may be used in treating a disease o
MCL-1 INHIBITORS AND METHODS OF USE THEREOF
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Page/Page column 45; 48; 51, (2018/10/25)
Disclosed are Mcl-1 inhibitors, pharmaceutical compositions comprising the same and methods of using the same.
Hypervalent Iodine as a Terminal Oxidant in Wacker-Type Oxidation of Terminal Olefins to Methyl Ketones
Chaudhari, Dipali A.,Fernandes, Rodney A.
, p. 2113 - 2121 (2016/03/15)
A mimic of the Wacker process for C=O bond formation in terminal olefins can be initiated by a combination of the Pd(II) and hypervalent iodine reagent, Dess-Martin periodinane to generate methyl ketones. This operationally simple and scalable method offers Markovnikov selectivity, has good functional group compatibility, and is mild and high yielding.