118629-73-5

Basic information

• Product Name: 1,2-Butanediol, 4-phenyl-, 1-(4-methylbenzenesulfonate), (2S)-
• CAS NO: 118629-73-5
• Molecular Formula: C17H20O4S
• Molecular Weight: 320.409
• Mol File: 118629-73-5.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1,2-Butanediol, 4-phenyl-, 1-(4-methylbenzenesulfonate), (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Butanediol, 4-phenyl-, 1-(4-methylbenzenesulfonate), (2S)-(118629-73-5)
• EPA Substance Registry System: 1,2-Butanediol, 4-phenyl-, 1-(4-methylbenzenesulfonate), (2S)-(118629-73-5)

Safety Data

• Hazardous Substances Data: 118629-73-5(Hazardous Substances Data)

Upstream product

• 1589-82-8 phenylmagnesium bromide 
• 70987-78-9 (S)-Glycidyl tosylate 
• 124988-64-3 (S)-4-phenyl-1,2-butanediol 
• 98-59-9 p-toluenesulfonyl chloride 
• 157732-87-1 (4S)-2,2-dimethyl-4-(2-phenylethyl)-1,3-dioxolane 
• 152203-65-1 (4S)-2,2-dimethyl-4-styryl-1,3-dioxolane 
• 1449-46-3 benzyltriphenylphosphonium bromide 
• 768-56-9 4-Phenylbut-1-ene 
• 113826-06-5 (R)-glycidyl tosylate 
• 6921-34-2 benzylmagnesium chloride 

Downstream Products

• 125103-96-0 (S)-5-phenyl-3-hydroxypentanenitrile 
• 182950-96-5 (6S)-6-(2-phenylethyl)dihydropyran-2,4⁽³⁾-dione 
• 587-63-3 7,8-dihydrokawain 
• 862464-32-2 methyl (5S)-5-hydroxy-3-oxo-7-phenylheptanoate 
• 913258-22-7 (S)-1,2-epoxy-4-phenylbutane 
• 41639-83-2 latanoprost acid 
• 913258-32-9 (Z)-3-hydroxy-2-(hydroxymethyl)-2-methylpropyl 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoate 
• 145773-22-4 isopropyl (E)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoate 
• 913258-20-5 (S)-4-phenyl-1-iodo-2-(triethylsiloxy)butane 
• 913258-23-8 (S)-2-hydroxy-1-iodo-4-phenylbutane 
• 913258-19-2 (S)-4-phenyl-1-(p-tolylsulfonyloxy)-2-(triethylsiloxy)butane 

Relevant articles and documents

Synthesis of yashabushidiol and its analogues and their cytotoxic activity against cancer cell lines

A total synthesis of yashabushidiol (1a), a linear diarylheptanoid having 1,3- diol system and its analogues has been achieved by alkynylation of 3-hydroxy-5-phenyl pentanal with substituted phenyl acetylenes. All the compounds have shown significant anti

A new synthetic approach to high-purity (15R)-latanoprost

This paper describes a new synthesis of latanoprost (1) that afforded high purity latanoprost in 16.9 % overall yield in eight synthetic steps from sulfone 4. The "a chain" in a derivative of the (-)-"Corey lactone" was elongated first, followed by the attachment of a novel, enantiomerically pure "ω chain" synthon. This ensured the absence of the undesired (15S)-1 diastereomer in the synthesized prostaglandin. The crystalline nature of the novel sulfone 4 facilitated its purification. A variation of the new synthesis of latanoprost is described, where the laboratory-scale synthesis was further adapted to a hundred-gram scale. In the course of the present synthesis, a new prostaglandin sulfone intermediate, 21, which may find application in the synthesis of diverse prostaglandin analogs, was introduced. A practical synthesis of novel, enantiomerically pure "ω chain" synthons 15, 16, and 17 has also been carried out, employing diol 12, which was obtained from derivatives of the D-mannitol chiral pool. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.

A total synthesis of (+)- and (-)-dihydrokavain with a sonochemical blaise reaction as the key step

Starting from 2,3-O-isopropylidene-D-glyceraldehyde (2) as chiral material, the naturally occurring (S)-(+)-dihydrokavain (1a) was synthesized by a procedure that involves a sonochemical Blaise reaction as the key step. The absolute configuration of (S)-(