1227594-82-2

Basic information

• Product Name: Methyl 3-fluoro-2-(trifluoromethyl)isonicotinate
• Synonyms: Methyl 3-fluoro-2-(trifluoromethyl)isonicotinate;4-Pyridinecarboxylicacid,3-fluoro-2-(trifluoromethyl)-,methylester;METHYL 3-FLUORO-2-(TRIFLUOROMETHYL)PYRIDINE-4-CARBOXYLATE
• CAS NO: 1227594-82-2
• Molecular Formula: C8H5F4NO2
• Molecular Weight: 223.13
• Mol File: 1227594-82-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 221.5±40.0 °C(Predicted)
• Appearance: /
• Density: 1.409±0.06 g/cm3(Predicted)
• PKA: -4.01±0.30(Predicted)
• CAS DataBase Reference: Methyl 3-fluoro-2-(trifluoromethyl)isonicotinate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-fluoro-2-(trifluoromethyl)isonicotinate(1227594-82-2)
• EPA Substance Registry System: Methyl 3-fluoro-2-(trifluoromethyl)isonicotinate(1227594-82-2)

Safety Data

• Hazardous Substances Data: 1227594-82-2(Hazardous Substances Data)

Usage

General Description

Methyl 3-fluoro-2-(trifluoromethyl)isonicotinate is a chemical compound with the formula C9H6F4NO2. It is a derivative of isonicotinic acid and contains a fluorine and trifluoromethyl group attached to the carbon atom. Methyl 3-fluoro-2-(trifluoromethyl)isonicotinate is used in the pharmaceutical and agrochemical industries as a building block for the synthesis of various biologically active compounds. It has potential applications in the development of new drugs and agrochemicals due to its unique structure and properties. Methyl 3-fluoro-2-(trifluoromethyl)isonicotinate may also be used as a research reagent in organic chemistry and medicinal chemistry laboratories.

Upstream product

• 876919-08-3 methyl 3-fluoropyridine-4-carboxylate 
• 2926-29-6 Langlois reagent 
• 67-56-1 methanol 
• 886510-09-4 2-trifluoromethyl-3-fluoro-4-pyridinecarboxylic acid 

Downstream Products

• 1227600-70-5 [3-fluoro-2-(trifluoromethyl)pyridin-4-yl]methanol 

Relevant articles and documents

Preparation method of 2-trifluoromethyl-3-fluoro-4-picolinic acid and derivatives thereof

The invention discloses a preparation method of 2-trifluoromethyl-3-fluoro-4-picolinic acid and derivatives thereof, and is characterized in that provided is the preparation method of 2-trifluoromethyl-3-fluoro-4-picolinic acid and the derivatives thereof by a method of introducing trifluoromethyl into 2-site of a polysubstituted pyridine ring through a free radical mechanism, wherein the preparation method is suitable for large-scale application. The method for directly carrying out trifluoromethylation reaction on the 2-site of 3-fluoro-4-pyridine carboxylic acid alkyl ester is reported forthe first time, and is simple and convenient in process, easily available in raw materials, high in conversion rate and simple in reaction post-treatment operation. Meanwhile, the selectivity of the method in introducing trifluoromethyl into the 2-site of pyridine is quite high, and a single product with trifluoromethyl substituted at the 2-site can be obtained only through simple recrystallization.

SUBSTITUTED 5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRIDINE-3(2H)-ONES AND 2,5,6,7-TETRAHYDRO-3H-PYRROLO[2,1-C][1,2,4]TRIAZOL-3-ONES, AND USE THEREOF

The present application relates to novel substituted 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-3(2H)-ones and 2,5,6,7-tetrahydro-3H-pyrrolo[2,1-c][1,2,4]triazol-3-ones, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of lung inflammation disorders.