122902-81-2

Basic information

• Product Name: Boc-N-Me-Ser-OMe
• Synonyms: Boc-N-Me-Ser-OMe
• CAS NO: 122902-81-2
• Molecular Formula: C₁₀H₁₉NO₅
• Molecular Weight: 233.26156
• Product Categories: amino acids
• Mol File: 122902-81-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Boc-N-Me-Ser-OMe(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-N-Me-Ser-OMe(122902-81-2)
• EPA Substance Registry System: Boc-N-Me-Ser-OMe(122902-81-2)

Safety Data

• Hazardous Substances Data: 122902-81-2(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 101772-29-6 (S)-2-((tert-butoxycarbonyl)(methyl)amino)-3-hydroxypropanoic acid 
• 74-88-4 methyl iodide 

Downstream Products

• 207570-20-5 (S)-2-(tert-Butoxycarbonyl-methyl-amino)-3-(toluene-4-sulfonyloxy)-propionic acid methyl ester 
• 397243-76-4 2-(tert-butoxycarbonyl-methyl-amino)-3-(4-phenoxy-benzenesulfonyl)-propionic acid methyl ester 
• 56776-34-2 N-Boc-N-methyl-dehydroalanine methyl ester 

Relevant articles and documents

NOVEL PSYCHOTROPIC AGENTS HAVING GLUTAMATE NMDA ACTIVITY

The invention provides novel compounds and pharmaceutical compositions for the treatment of psychological and/or psychiatric diseases or disorders.

Total Synthesis of TAN-1057 A/B, a New Dipeptide Antibiotic from Flexibacter sp. PK-74

TAN-1057 (1a, b) - a new natural dipeptide antibiotic active against methicillin resistant strains of Staphylococcus aureus - was synthesized starting from Na,Nδ,Nω-tri-Z-L-arginine 20b via the corresponding diazoketone 21b. This upon photolysis rearranged to the ketene which was trapped by (±)-2,4,5,6-tetrahydro-5-methylamino-2-ureidopyrimidin-4-one (3) to yield the fully protected dipeptide 23 (30%). The latter was deprotected by hydrogenolysis to give the final compound as a mixture of two epimers - TAN-1057A, B - isolated previously from a strain of Flexibacter sp. PK-74. The intermediate 3 was prepared from 3-amino-2-(N-Z-N-methylamino)propionic acid methyl ester hydrochloride (16) and 2-methyl-2-thiopseudobiuret hydroiodide (18) in one step in 35% yield.