124506-31-6

Basic information

• Product Name: (R)-Tetrahydrofuran-3-ylm...
• Synonyms: (R)-Tetrahydrofuran-3-ylm...;(3R)-oxolan-3-ylMethanol;(R)-Tetrahydrofuran-3-ylMethanol;(3R)-tetrahydro-3-Furanmethanol;[(3R)-Tetrahydrofuran-3-yl]methanol
• CAS NO: 124506-31-6
• Molecular Formula: C₅H₁₀O₂
• Molecular Weight: 102.1317
• Mol File: 124506-31-6.mol
• Article Data: 28

Chemical Properties

• Boiling Point: 198.6±0.0 °C(Predicted)
• Appearance: /
• Density: 1.038±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 14.81±0.10(Predicted)
• CAS DataBase Reference: (R)-Tetrahydrofuran-3-ylm...(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-Tetrahydrofuran-3-ylm...(124506-31-6)
• EPA Substance Registry System: (R)-Tetrahydrofuran-3-ylm...(124506-31-6)

Safety Data

• Hazardous Substances Data: 124506-31-6(Hazardous Substances Data)

Usage

General Description

"(R)-Tetrahydrofuran-3-ylmethylamine" or "(R)-THF-3-ylmethylamine" is a derivative of tetrahydrofuran, a well-known organic compound. The structure and exact properties of this kind of chemical can vary somewhat depending on the additional groups attached to the base tetrahydrofuran molecule, although it generally retains a number of important chemical characteristics. Often, these kinds of compounds serve as intermediates in a variety of complex organic syntheses. Each of these compounds is classified as a member of the tetrahydrofurans, which are heterocyclic compounds with a five-membered ring structure consisting of four carbon atoms and one oxygen atom. Due to their potential utility in synthesizing other compounds, stereospecific variants like (R)-Tetrahydrofuran-3-ylmethylamine are an area of considerable research in organic chemistry.

Upstream product

• 15424-04-1 2-(allyloxy)ethyl bromide 
• 79710-86-4 tetrahydrofuran-3-carboxaldehyde 
• 69595-02-4 tetrahydrofuran-3-carbonyl chloride 
• 89364-31-8 3-tetrahydrofuroic acid 
• 168395-26-4 (S)-tetrahydro-furan-3-carboxylic acid 
• 1050496-32-6 (S)-2-([(tetrahydro-3-furanylmethyl)oxy]carbonyl)benzoic acid 
• 1050496-18-8 (4R)-4-(phenylmethyl)-3-[(3S)-tetrahydro-3-furanylcarbonyl]-1,3-oxazolidin-2-one 
• 322639-11-2 (4S)-4-(phenylmethyl)-3-[(3S)-tetrahydro-3-furanylcarbonyl]-1,3-oxazolidin-2-one 
• 1708-29-8 2,5-dihydrofuran 
• 74-97-5 chlorobromomethane 
• 109-99-9 tetrahydrofuran 
• 67-56-1 methanol 
• 5472-38-8 diethyl 2-formylbutanedioate 
• 18132-98-4 α-hydroxymethyl-γ-butyrolactone 

Downstream Products

• 13423-15-9 3-methyltetrahydrofuran 
• 64190-48-3 dihydro-4-methyl-2(3H)-furanone 
• 1679-47-6 3-methyltetrahydro-2-furanone 
• 1050496-28-0 2-([(tetrahydro-3-furanylmethyl)oxy]carbonyl)benzoic acid 
• 89181-22-6 3-(chloromethyl)tetrahydrofuran 
• 1365033-53-9 methyl 4-fluoro-2-(tetrahydrofuran-3-ylmethoxy)benzoate 
• 1100987-19-6 (±)-3-ethynyltetrahydrofuran 
• 165253-31-6 (tetrahydro-3-furanyl)methylamine 
• 53662-85-4 methyl tetrahydrofuran-3-carboxylate 
• 1194597-02-8 (3S)-tetrahydrofuran-3-ylmethyl 4-methylbenzenesulfonate 

Relevant articles and documents

3-(5-METHOXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF

The present disclosure relates to compounds of formula (I') and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.

Preparation method of tetrahydro-3-furanmethanol

The invention relates to the field of preparation of insecticides, in particular to a preparation method of tetrahydro-3-furanmethanol. The method comprises the steps as follows: 13.6 g of sodium ethoxide and 0.5 g of sodium iodide are dissolved in 120 mL of absolute ethyl alcohol, 32 g of diethyl malonate is dropwise added in an ice-water bath, the temperature is controlled at 20 DEG C or below,stirring is performed continuously for 1 h after addition, then 30.3 g of ethyl bromoacetate is slowly added, the temperature is increased to 50-60 DEG C after addition, stirring is performed for about 8 h, ethyl bromoacetate is detected to be used up through gas chromatography, a heating reaction is stopped, the system is cooled to the room temperature, 10 mL of a saturated ammonium chloride solution is added with stirring, the system is adjusted to be neutral or slightly acid, solvent ethyl alcohol is evaporated, residues are dissolved in 100 mL of water and 100 mL of ethyl acetate for extraction, solution separation is performed, an organic phase is separated, the solvent ethyl acetate is removed from the organic phase, reduced pressure distillation is performed through an oil pump, andthe first fraction point, namely, a triethyl 1,1,2-ethanetricarboxylate product, is collected. The process is simple, safety in actual production is guaranteed, and the product with higher yield is obtained.

Production technology for 3-hydroxymethyltetrahydrofuran

The invention discloses a production technology for 3-hydroxymethyltetrahydrofuran, and belongs to the field of pesticide intermediate synthetic processes. The production technology is capable of using 2-butene-1,4-diol as a starting raw material, and synthesizing the 3-hydroxymethyltetrahydrofuran through a three-step reaction of dehydration cyclization, hydroformylation and reduction. The production technology is moderate in reaction conditions, low in cost, less in three wastes, and suitable for the industrial production.