125419-80-9

Basic information

• Product Name: 3,5-Dibromo-4-ethylpyridine
• Synonyms: 3,5-Dibromo-4-ethylpyridine
• CAS NO: 125419-80-9
• Molecular Formula: C₇H₇Br₂N
• Molecular Weight: 264.94518
• Mol File: 125419-80-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 259℃
• Flash Point: 110℃
• Appearance: /
• Density: 1.792
• CAS DataBase Reference: 3,5-Dibromo-4-ethylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Dibromo-4-ethylpyridine(125419-80-9)
• EPA Substance Registry System: 3,5-Dibromo-4-ethylpyridine(125419-80-9)

Safety Data

• Hazardous Substances Data: 125419-80-9(Hazardous Substances Data)

Usage

General Description

3,5-Dibromo-4-ethylpyridine is a chemical compound with the molecular formula C7H7Br2N. It is a white to light yellow crystalline powder that is soluble in organic solvents. 3,5-Dibromo-4-ethylpyridine is often used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It has also been found to exhibit biocidal properties, making it useful in the development of antimicrobial and antifungal agents. Additionally, it is a valuable reagent in organic synthesis and can be used in the production of specialty chemicals. Due to its potential applications in various industries, 3,5-Dibromo-4-ethylpyridine is an important compound with diverse uses.

Upstream product

• 625-92-3 3,5-dibromopyridine 
• 75-03-6 ethyl iodide 
• 74-88-4 methyl iodide 
• 536-75-4 4-Ethylpyridine 

Downstream Products

• 1373522-31-6 4-(5-(5-(3-cyano-4-isobutylphenyl)-1,2,4-thiadiazol-3-yl)-4-ethylpyridin-3-yl)butanoic acid 
• 1373522-30-5 4-(5-(5-(3-chloro-4-isopropoxyphenyl)-1,2,4-thiadiazol-3-yl)-4-ethylpyridin-3-yl)butanoic acid 
• 1373522-81-6 5-(3-(5-bromo-4-ethylpyridin-3-yl)-1,2,4-thiadiazol-5-yl)-2-isobutylbenzonitrile 
• 1373522-80-5 3-(5-bromo-4-ethylpyridin-3-yl)-5-(3-chloro-4-isopropoxyphenyl)-1,2,4-thiadiazole 
• 1373522-79-2 3-(5-bromo-4-ethylpyridin-3-yl)-5-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-thiadiazole 
• 1373522-78-1 (5-bromo-4-ethylpyridin-3-yl)boronic acid 

Relevant articles and documents

Synthesis of 4-alkyl-3,5-dibromo-, 3-bromo-4,5-dialkyl- and 3,4,5-trialkylpyridines via sequential metalation and metal-halogen exchange of 3,5-dibromopyridine

Lithiation of 3,5-dibromopyridine with LDA and subsequent reaction with electrophiles provided 4-alkyl-3,5-dibromopyridines 2 in high yield. 3-Bromo-4,5-dialkylpyridines 3 were synthesized by metal-halogen exchange of 2 with one equivalent n-BuLi and reaction with a second electrophile. Further metal-halogen exchange of 3 and reaction with a third electrophile provided 3,4,5-trisubstituted pyridines 4.

Discovery of novel 1,2,4-thiadiazole derivatives as potent, orally active agonists of sphingosine 1-phosphate receptor subtype 1 (S1P1)

A novel series of 1,2,4-thiadiazole compounds was discovered as selective S1P1 agonists. The extensive structure-activity relationship studies for these analogues were reported. Among them, 17g was identified to show high in vitro potency with reasonable free unbound fraction in plasma (Fu > 0.5%), good brain penetration (BBR > 0.5), and desirable pharmacokinetic properties in mouse and rat. Oral administration of 1 mg/kg 17g resulted in significant peripheral lymphocytes reduction at 4 h after dose and rapid lymphocytes recovery at 24 h. 17g showed a transient lymphopenia profile in the repeated dose study in mouse. In addition, 17g also demonstrated efficacy comparable to that of FTY720 (1) in the mouse EAE model of MS.