133737-32-3

Basic information

• Product Name: PAGOCLONE
• Synonyms: RP 59037;Ip 456;Rp 62955;2-(7-Chloro-1,8-naphthyridin-2-yl)-3-(5-Methyl-2-oxohexyl)isoindolin-1-one;2-(7-Chloro-1,8-naphthyridin-2-yl)-3-(5-methyl-2-oxohexyl)-1-isoindolinone
• CAS NO: 133737-32-3
• Molecular Formula: C₂₃H₂₂ClN₃O₂
• Molecular Weight: 407.899
• Mol File: 133737-32-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 582.1°Cat760mmHg
• Flash Point: 305.9°C
• Appearance: /
• Density: 1.273g/cm³
• Vapor Pressure: 1.53E-13mmHg at 25°C
• Refractive Index: 1.625
• PKA: 1.62±0.30(Predicted)
• CAS DataBase Reference: PAGOCLONE(CAS DataBase Reference)
• NIST Chemistry Reference: PAGOCLONE(133737-32-3)
• EPA Substance Registry System: PAGOCLONE(133737-32-3)

Safety Data

• Hazardous Substances Data: 133737-32-3(Hazardous Substances Data)

Usage

Uses

Anti-anxiety agent.

Brand name

Bextra (Interneuron).

InChI:InChI=1/C23H22ClN3O2/c1-14(2)7-10-16(28)13-19-17-5-3-4-6-18(17)23(29)27(19)21-12-9-15-8-11-20(24)25-22(15)26-21/h3-6,8-9,11-12,14,19H,7,10,13H2,1-2H3

Upstream product

• 42809-49-4 6-methyl-1-hepten-3-one 
• 100-52-7 benzaldehyde 
• 55243-02-2 2,7-dichloro-1,8-naphthyridine 
• 15944-33-9 2-chloro-7-amino-1,8-naphthyridine 
• 33779-03-2 2-(2-methoxycarbonylethyl)benzoic acid 
• 3849-22-7 (3-oxo-2,3-dihydro-1H-isoindol-1-yl)-acetic acid 
• 55112-41-9 2-hydroxy-7-N-phthalimidyl-1,8-naphthyridine 
• 632620-24-7 2-amino-7-hydroxy-1,8-naphthyridine sulfate 
• 134664-69-0 isoamylcarbonylmethylenetriphenyl phosphorane 
• 55112-38-4 2-(7-chloro-1,8-naphthyridin-2-yl)-3-hydroxy-isoindolin-1-one 
• 141-86-6 2.6-diaminopyridine 
• 110-12-3 5-Methyl-2-hexanone 
• 136604-91-6 [(5-methyl-2-oxo)hexyl]triphenylphosphonium bromide 
• 147031-30-9 (±)-2-[1-(7-chloro-1,8-naphthyridin-2-ylamino)-6-methyl-3-oxoheptyl]benzoic acid 

Downstream Products

• 147031-30-9 (±)-2-[1-(7-chloro-1,8-naphthyridin-2-ylamino)-6-methyl-3-oxoheptyl]benzoic acid 

Relevant articles and documents

Preparation method of anti-anxiety drug pagoclone or pazinaclone

The invention discloses a method for catalytically synthesizing an anti-anxiety drug pagoclone or pazinaclone and analogues thereof by utilizing Rh(III). The method comprises the following steps: reacting benzaldehyde and 2-aminopyridine compounds in a solvent in the presence of a rhodium catalyst and acetate, and producing an effective guide group in situ; and reacting the guide group and substituted olefin under rhodium catalysis, and performing after-treatment after the reaction is completed, thereby obtaining a compound having a nitrogen heterocyclic framework. According to the preparationmethod, two independent reactions (amide formation and carbon-hydrogen activation) are catalyzed by using rhodium, and a synthetic strategy of self-assembling high-efficiency guide groups is successfully realized. The reaction is carried out based on simple raw materials, an isoindoxone skeleton having substitution characteristics is synthesized in a simple and mild catalytic system by utilizinga 'one-pot process', the operation is simple and convenient, the reaction conditions are mild, the yield is high, and atom economy is high.

Cu/Fe Catalyzed Intermolecular Oxidative Amination of Benzylic C-H Bonds

We report a Cu/Fe co-catalyzed Ritter-type C-H activation/amination reaction that allows efficient and selective intermolecular functionalization of benzylic C-H bonds. This new reaction is featured by simple reaction conditions, readily available reagents and general substrate scope, allowing facile synthesis of biologically interesting nitrogen containing heterocycles. The Cu and Fe salts were found to play distinct roles in this cooperative catalysis. With a little help: A Ritter-type intermolecular amination of benzylic C-H bonds with acetonitrile, co-catalyzed by CuII/FeIII is reported. A wide array of biologically interesting nitrogen containing heterocycles was prepared from 2-alkyl benzoic acids and heteroaromatic carboxylic acids under operationally simple conditions. The Cu and Fe salts were found to play distinct roles in this cooperative catalysis.

Methods for making 2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone

The present invention relates to methods for making racemic 2-(7-chloro-1,8-naphthyridin-2-yl)-3-(5-methyl-2-oxohexyl)-1-isoindolinone and (+)-2-(7-chloro-1,8-naphthyridine-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isoindolinone.