1338789-19-7Relevant articles and documents
Combining X-ray crystallography and molecular modeling toward the optimization of pyrazolo[3,4-d ]pyrimidines as potent c-Src inhibitors active in vivo against neuroblastoma
Tintori, Cristina,Fallacara, Anna Lucia,Radi, Marco,Zamperini, Claudio,Dreassi, Elena,Crespan, Emmanuele,Maga, Giovanni,Schenone, Silvia,Musumeci, Francesca,Brullo, Chiara,Richters, André,Gasparrini, Francesca,Angelucci, Adriano,Festuccia, Claudio,Delle Monache, Simona,Rauh, Daniel,Botta, Maurizio
, p. 347 - 361 (2015/02/19)
c-Src is a tyrosine kinase belonging to the Src-family kinases. It is overexpressed and/or hyperactivated in a variety of cancer cells, thus its inhibition has been predicted to have therapeutic effects in solid tumors. Recently, the pyrazolo[3,4-d]pyrimi