1338789-21-1Relevant articles and documents
Combining X-ray crystallography and molecular modeling toward the optimization of pyrazolo[3,4-d ]pyrimidines as potent c-Src inhibitors active in vivo against neuroblastoma
Tintori, Cristina,Fallacara, Anna Lucia,Radi, Marco,Zamperini, Claudio,Dreassi, Elena,Crespan, Emmanuele,Maga, Giovanni,Schenone, Silvia,Musumeci, Francesca,Brullo, Chiara,Richters, André,Gasparrini, Francesca,Angelucci, Adriano,Festuccia, Claudio,Delle Monache, Simona,Rauh, Daniel,Botta, Maurizio
, p. 347 - 361 (2015/02/19)
c-Src is a tyrosine kinase belonging to the Src-family kinases. It is overexpressed and/or hyperactivated in a variety of cancer cells, thus its inhibition has been predicted to have therapeutic effects in solid tumors. Recently, the pyrazolo[3,4-d]pyrimi
Identification of potent c-Src inhibitors strongly affecting the proliferation of human neuroblastoma cells
Radi, Marco,Brullo, Chiara,Crespan, Emmanuele,Tintori, Cristina,Musumeci, Francesca,Biava, Mariangela,Schenone, Silvia,Dreassi, Elena,Zamperini, Claudio,Maga, Giovanni,Pagano, Dafne,Angelucci, Adriano,Bologna, Mauro,Botta, Maurizio
, p. 5928 - 5933 (2011/10/18)
Neuroblastoma (NB) represents the most common extracranial paediatric solid tumor for which no specific FDA-approved treatment is currently available. The tyrosine kinase c-Src has been reported to play an important role in the differentiation, cell-adhes