13580-86-4 Usage
Description
4-Chlorophthalazin-1-ylamine is an organic compound with the molecular formula C8H6ClN3. It is a derivative of phthalazine, a heterocyclic compound consisting of a fused six-membered benzene ring and a seven-membered nitrogen-containing ring. The presence of a chlorine atom at the 4-position and an amine group at the 1-position provides this compound with unique chemical properties and potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
4-Chlorophthalazin-1-ylamine is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its ability to form derivatives with potential biological activities makes it a valuable building block in the development of new drugs.
Used in Anthelmintic Applications:
In the veterinary pharmaceutical industry, 4-chlorophthalazin-1-ylamine is used as a starting material to prepare 2-phenylimidazo[1,2-b]pyridazine derivatives. These derivatives exhibit anthelminthic properties, making them effective against parasitic worms, particularly Haemonchus contortus, a common gastrointestinal parasite in sheep and goats.
Used in Inhibitor Development:
4-Chlorophthalazin-1-ylamine is also utilized in the synthesis of imidazo[2,1-a]phthalazines, which are potential inhibitors of p38 MAP kinase. This enzyme plays a crucial role in various cellular processes, including inflammation, immune responses, and cell growth. Inhibiting p38 MAP kinase activity can be beneficial in the treatment of various diseases, such as autoimmune disorders and cancer.
Used in Computational Biology:
The compound is employed in the prediction of binding affinities of protein ligands, which is an essential aspect of drug design and development. By understanding how 4-chlorophthalazin-1-ylamine interacts with target proteins, researchers can gain insights into its potential applications and optimize its properties for specific therapeutic purposes.
Check Digit Verification of cas no
The CAS Registry Mumber 13580-86-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,5,8 and 0 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 13580-86:
(7*1)+(6*3)+(5*5)+(4*8)+(3*0)+(2*8)+(1*6)=104
104 % 10 = 4
So 13580-86-4 is a valid CAS Registry Number.
InChI:InChI=1/C8H6ClN3/c9-7-5-3-1-2-4-6(5)8(10)12-11-7/h1-4H,(H2,10,12)
13580-86-4Relevant articles and documents
PHTHALAZINE DERIVATIVES
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Page/Page column 42, (2015/01/16)
Compounds of the formula (I), in which R1, X and n have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous syst
TRIAZOLO-PYRIDAZINE COMPOUNDS AND DERIVATIVES THEREOF USEFUL IN THE TREATMENT OF NEUROPATHIC PAIN
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Page/Page column 92; 96; 100, (2010/02/11)
The present invention is directed to a method of use of triazolo-pyridazine compounds in the treatment of neuropathic pain. The present invention is also directed to the use of triazolo-pyridazine compounds in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, bipolar disorders, and panic, as well as in the treatment of pain, Parkinson’s disease, cognitive dysfunction, epilepsy, circadian rhythm and sleep disorders - such as shift-work induced sleep disorder and jet-lag, drug addiction, drug abuse, drug withdrawal and other diseases. The present invention is also directed to novel triazolo-pyridazine compounds that selectively bind to α2δ-1 subunit of Ca channels.
