449187-73-9Relevant articles and documents
Synthesis of Imidazo[2,1-a]phthalazines, Potential Inhibitors of p38 MAP Kinase. Prediction of Binding Affinities of Protein Ligands
Mavel, Sylvie,Thery, Isabelle,Gueiffier, Alain
, p. 7 - 14 (2007/10/03)
Based upon molecular modeling, the pharmacophore of potential inhibitors of p38 MAPK (mitogen-activated protein kinases) is discussed and the predictive binding affinities are calculated. Synthesis of original diarylimidazo[2,1-a]phthalazines obtained by