1360452-45-4Relevant articles and documents
Concise synthesis of (+)-conduritol F and inositol analogues from naturally available (+)-proto-quercitol and their glucosidase inhibitory activity
Worawalai, Wisuttaya,Rattanangkool, Eakkaphon,Vanitcha, Avassaya,Phuwapraisirisan, Preecha,Wacharasindhu, Sumrit
, p. 1538 - 1540 (2012)
An effective synthesis of (+)-conduritol F, (+)-chiro- and (+)-epi-inositols from naturally available (+)- proto-quercitol is described. This synthetic method provides a concise synthesis of cyclitols in enantiomerically pure form. Of the synthesized cyclitols, (+)-conduritol F potently inhibits type I α-glucosidase with an IC50 value of 86.1 lM, which is five times greater than the standard antidiabetic drug, acarbose.
