1365246-90-7

Basic information

• Product Name: C₅₈H₇₃FN₆O₁₂S
• CAS NO: 1365246-90-7
• Molecular Weight: 1097.32
• Mol File: 1365246-90-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₅₈H₇₃FN₆O₁₂S(CAS DataBase Reference)
• NIST Chemistry Reference: C₅₈H₇₃FN₆O₁₂S(1365246-90-7)
• EPA Substance Registry System: C₅₈H₇₃FN₆O₁₂S(1365246-90-7)

Safety Data

• Hazardous Substances Data: 1365246-90-7(Hazardous Substances Data)

Upstream product

• 626-29-9 myristic anhydride 
• 25526-93-6 alovudine 
• 2419-56-9 L-glutamic acid 5-tert-butyl ester 
• 1365246-88-3 N-myristoyl-Glu(OtBu)-OFLT 
• 956897-01-1 (-)-N⁽⁴⁾-(4,4'-dimethoxytrityl)-2',3'-dideoxy-3'-thiacytidine 
• 1365246-89-4 N-myristoyl-Glu(OH)-OFLT 

Relevant articles and documents

Synthesis and anti-HIV activities of glutamate and peptide conjugates of nucleoside reverse transcriptase inhibitors

Mono-, di-, and trinucleoside conjugates of glutamate or peptide scaffolds containing nucleoside reverse transcriptase inhibitors were synthesized. Among dinucleoside glutamate ester derivatives, N-myristoylated derivatives showed significantly higher anti-HIV activity than the corresponding N-acetylated conjugates against cell-free virus. Myristoyl-Glu(3TC)-FLT (46, EC50 = 0.3-0.6 μM) and myristoyl-Glu(FTC)-FLT (47, EC50 = 0.1-0.4 μM) derivatives were the most active glutamate-dinucleoside conjugates. A trinucleoside glutamate derivative containing AZT, FLT, and 3TC (34, EC 50 = 0.9-1.4 μM) exhibited higher anti-HIV activity than AZT and 3TC against cell-free virus. Compound 34 also exhibited higher anti-HIV activity against multidrug (IC50 = 5.9 nM) and NNRTI (IC50 = 12.9 nM) resistant viruses than parent nucleosides. The physical mixture containing FLT-succinate, AZT, 3TC, and glutamic acid exhibited 115-fold less activity against cell associated virus (EC50 = 91.9 μM) when compared to 34 (EC50 = 0.8 μM). Other conjugates showed less or comparable potency to that of the corresponding physical mixtures.