1384870-47-6 Usage
Description
DBCO-C6-NHS ester is an amine-reactive compound that is utilized for modifying amine-containing molecules in organic media. It is characterized by an extended 6-carbon atom spacer arm, which enhances solubility in commonly used organic solvents such as dichloromethane, chloroform, THF, and ethyl acetate. This feature also improves the derivatization efficiency and stability of the resulting conjugates. DBCO-C6-NHS ester is widely recognized for its application in copper-free Click Chemistry reactions, making it a valuable tool in various research and industrial settings.
Uses
Used in Chemical Synthesis:
DBCO-C6-NHS ester is used as a synthetic building block for the creation of complex molecules and conjugates. Its amine reactivity and extended spacer arm facilitate the formation of stable and efficient molecular constructs.
Used in Bioconjugation:
In the field of bioconjugation, DBCO-C6-NHS ester is employed as a coupling agent to attach biomolecules, such as proteins, peptides, and oligonucleotides, to other molecules or surfaces. The extended spacer arm improves the stability and efficiency of these conjugates, making it a preferred choice for various applications.
Used in Drug Development:
DBCO-C6-NHS ester is used as a key component in the development of new drugs, particularly in the creation of drug conjugates. Its ability to form stable bonds with amine-containing drug molecules allows for the development of targeted therapies with improved efficacy and reduced side effects.
Used in Material Science:
In material science, DBCO-C6-NHS ester is utilized as a functionalizing agent to modify the surface properties of various materials. The extended spacer arm and amine reactivity enable the creation of novel materials with enhanced properties, such as improved biocompatibility or increased stability.
Used in Diagnostics:
DBCO-C6-NHS ester is used as a labeling agent in the development of diagnostic tools, such as immunoassays and biosensors. Its ability to form stable conjugates with amine-containing biomolecules allows for the creation of highly sensitive and specific diagnostic platforms.
Used in Research:
In academic and industrial research settings, DBCO-C6-NHS ester is employed as a versatile reagent for a wide range of applications, including the study of molecular interactions, the development of new chemical methodologies, and the exploration of novel biological processes. Its compatibility with copper-free Click Chemistry reactions makes it a popular choice for researchers seeking to develop new synthetic strategies and tools.
Check Digit Verification of cas no
The CAS Registry Mumber 1384870-47-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,8,4,8,7 and 0 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1384870-47:
(9*1)+(8*3)+(7*8)+(6*4)+(5*8)+(4*7)+(3*0)+(2*4)+(1*7)=196
196 % 10 = 6
So 1384870-47-6 is a valid CAS Registry Number.
1384870-47-6Relevant articles and documents
Manipulating the Click Reactivity of Dibenzoazacyclooctynes: From Azide Click Component to Caged Acylation Reagent by Silver Catalysis
Ao, Jiwei,Huang, He,Huang, Wei,Jiang, Bofeng,Liu, Junjie,Ren, Xuelian,Shi, Wei,Tang, Feng,Tang, Yubo,Yang, Weibo,Yu, Qun
, p. 19940 - 19944 (2020/09/02)
Strain-promoted azide–alkyne cycloaddition using dibenzoazacyclooctyne (DBCO) is widely applied in copper-free bioorthogonal reactions. Reported here is the efficient acid-promoted rearrangement and silver-catalyzed amidation of DBCO, which alters its click reactivity robustly. In the switched click reaction, DBCO, as a caged acylation reagent, enables rapid peptide/protein modification after decaging facilitated by silver catalysts, rendering site-specific conjugation of an IgG antibody by a Fc-targeting peptide.
