138772-65-3

Basic information

• Product Name: tert-butyl ((2S)-1-(((2S)-1-hydroxy-3-phenylpropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate
• Synonyms: tert-butyl ((2S)-1-(((2S)-1-hydroxy-3-phenylpropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate
• CAS NO: 138772-65-3
• Molecular Weight: 398.502
• Mol File: 138772-65-3.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: tert-butyl ((2S)-1-(((2S)-1-hydroxy-3-phenylpropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl ((2S)-1-(((2S)-1-hydroxy-3-phenylpropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate(138772-65-3)
• EPA Substance Registry System: tert-butyl ((2S)-1-(((2S)-1-hydroxy-3-phenylpropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate(138772-65-3)

Safety Data

• Hazardous Substances Data: 138772-65-3(Hazardous Substances Data)

Upstream product

• 3182-95-4 L-Phenylalaninol 
• 3674-06-4 Boc-Phe-ONSu 
• 63-91-2 L-phenylalanine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 51987-73-6 (S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 13122-89-9 (S)-methyl 2-((S)-2-(tert-butoxycarbonylamino)-3-phenylpropanamido)-3-phenylpropanoate 
• 13122-90-2 Boc-Phe-Phe-OH 
• 67729-36-6 Boc-Phe-O-COO-isoBu 

Downstream Products

• 94343-39-2 (S)-2-amino-N-((S)-1-hydroxy-3-phenylpropan-2-yl)-3-phenylpropanamide 
• 383129-51-9 Boc-Phe-Phe-H 
• 80780-41-2 aurantiamide acetate 
• 138772-73-3 Acetic acid (S)-2-((S)-2-amino-3-phenyl-propionylamino)-3-phenyl-propyl ester; compound with trifluoro-acetic acid 
• 153864-35-8 tert-butyl (S)-1-oxo-3-phenyl-1-((S)-1-phenylbut-3-en-2-ylamino)propan-2-ylcarbamateas 
• 1414493-15-4 tert-butyl (2S,5S,6S)-2,5-dibenzyl-6-(iodomethyl)-3-oxopiperazine-1-carboxylate 

Relevant articles and documents

Aurantiamide acetate and fluorinated derivatives thereof as well as preparation method and application thereof

The invention belongs to the technical field of medicines, and discloses aurantiamide acetate and fluorinated derivatives thereof, and a preparation method and application thereof. The general formulaof the aurantiamide acetate, the aurantiamide acetate fluorinated derivatives or pharmaceutically acceptable salts of the aurantiamide acetate and the aurantiamide acetate fluorinated derivatives isshown in the specification, wherein R1 represents OH, CH2OH or OCOCH3, and R2, R3 and R4 each independently represent H, an alkyl group or F. The aurantiamide acetate and the fluorinated derivatives or the pharmaceutically acceptable salts thereof have a good effect of preventing or treating influenza viruses, especially infection caused by influenza A viruses. The aurantiamide acetate is subjected to fluorination modification, so that the biological activity of the aurantiamide acetate is stronger. The aurantiamide acetate and the fluorinated derivative thereof act on a target to aim at viruses and also aim at host cells, so that drug resistance is not easy to generate.

An efficient entry to highly substituted chiral 2-oxopiperazines from α-amino acids via iodocyclization

A short and stereoselective route for the synthesis of 2-oxopiperazines is presented starting from different naturally abundant α-amino acids. The key synthetic steps involved amide coupling, Wittig reaction, HWE olefination, aza-Michael reaction, iodocyc

PHENYLALANINE DIPEPTIDE DERIVATIVES, COMPOSITIONS AND USE THEREOF

Disclosed are a compound of formula I, stereoisomers, pharmaceutically acceptable salts or hydrates thereof, a pharmaceutical composition comprising the smae, a process for preparing the same and use thereof. The compound may also be used to prepare a medicament to treat viral infections, especially to prepare a medicament to treat hepatitis B virus and human immunodeficiency virus with little toxic side effects.