142212-08-6

Basic information

• Product Name: Formamide,N-(4-fluorophenyl)-N-methyl-(9CI)
• Synonyms: Formamide,N-(4-fluorophenyl)-N-methyl-(9CI)
• CAS NO: 142212-08-6
• Molecular Formula: C₈H₈FNO
• Molecular Weight: 153.1536232
• Product Categories: HALIDE
• Mol File: 142212-08-6.mol
• Article Data: 25

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Formamide,N-(4-fluorophenyl)-N-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Formamide,N-(4-fluorophenyl)-N-methyl-(9CI)(142212-08-6)
• EPA Substance Registry System: Formamide,N-(4-fluorophenyl)-N-methyl-(9CI)(142212-08-6)

Safety Data

• Hazardous Substances Data: 142212-08-6(Hazardous Substances Data)

Upstream product

• 64-18-6 formic acid 
• 459-59-6 4-fluoro-N-methylaniline 
• 459-25-6 N-(4-fluorophenyl)formamide 
• 74-88-4 methyl iodide 
• 403-46-3 4-fluoro-N,N-dimethylaniline 
• 109-94-4 formic acid ethyl ester 
• 667-27-6 Ethyl bromodifluoroacetate 
• 140-88-5 ethyl acrylate 
• 107-31-3 Methyl formate 
• 123-39-7 N-Methylformamide 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 124-38-9 carbon dioxide 
• 149-73-5 trimethyl orthoformate 
• 459-57-4 4-fluorobenzaldehyde 

Downstream Products

• 535920-90-2 7-fluoro-4-(4-fluorophenyl)-1-methylbenzo[f][1,4]-diazepine-2,3-dicarboxylic anhydride 
• 459-59-6 4-fluoro-N-methylaniline 
• 180140-14-1 5,5'-Difluoro-N³,N^3'-bis-(4-fluoro-phenyl)-1,1',N³,N^3'-tetramethyl-1H,1'H-[2,2']biindolyl-3,3'-diamine 
• 208177-07-5 (E)-1,2-Dichloro-N,N'-bis-(4-fluoro-phenyl)-N,N'-dimethyl-ethene-1,2-diamine 
• 773-91-1 5-fluoro-1-methylisatin 
• 403-46-3 4-fluoro-N,N-dimethylaniline 

Relevant articles and documents

Immobilization of ionic liquids to covalent organic frameworks for catalyzing the formylation of amines with CO2 and phenylsilane

We presented the immobilization of ionic liquids on the channel walls of COFs using a post-synthetic strategy. The ionic [Et4NBr]50%-Py-COF afforded a high CO2 adsorption capacity of 164.6 mg g-1 (1 bar, 273 K) and was developed as an effective heterogeneous catalyst for the transformation of CO2 into value-added formamides under ambient conditions.

Catalyst freeN-formylation of aromatic and aliphatic amines exploiting reductive formylation of CO2using NaBH4

Herein, we report a sustainable approach forN-formylation of aromatic as well as aliphatic amines using sodium borohydride and carbon dioxide gas. The developed approach is catalyst free, and does not need pressure or a specialized reaction assembly. The reductive formylation of CO2with sodium borohydride generates formoxy borohydride speciesin situ, as confirmed by1H and11B NMR spectroscopy. Thein situformation of formoxy borohydride species is prominent in formamide based solvents and is critical for the success of theN-formylation reactions. The formoxy borohydride is also found to promote transamidation reactions as a competitive pathway along with reductive functionalization of CO2with amine leading toN-formylation of amines.

Zinc Powder Catalysed Formylation and Urealation of Amines Using CO2 as a C1 Building Block?

Transformation of CO2 into valuable organic compounds catalysed by cheap and biocompatible metal catalysts is one of important topics of current organic synthesis and catalysis. Herein, we report the zinc powder catalysed formylation and urealation of amines with CO2 and (EtO)3SiH under solvent free condition. Using 2 molpercent zinc powder as the catalyst, a series of secondary amines, both the aromatic ones and the aliphatic ones, can be formylated into formamides. When primary aromatic amines were used as the substrates, the reactions produce urea derivatives. The electronic and steric effects from the substrates on the formylation and urealation reactions were observed and discussed. The recovery and reusability of zinc powder were investigated, showing the zinc powder can be reused in the formylation reaction without loss of catalytic activity. The analysis on the reactants/products mixture after filtering out the zinc powder showed the zinc concentration in the mixture is low to 1 ppm. The pathways for the formylation and urealation of amines with this catalytic system were also investigated, and related to the different substrates.