143314-51-6

Basic information

• Product Name: 2-hydroxy-N-methoxy-N-methyl-2-phenylacetamide
• Synonyms: 2-hydroxy-N-methoxy-N-methyl-2-phenylacetamide
• CAS NO: 143314-51-6
• Molecular Weight: 195.218
• Mol File: 143314-51-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-hydroxy-N-methoxy-N-methyl-2-phenylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-N-methoxy-N-methyl-2-phenylacetamide(143314-51-6)
• EPA Substance Registry System: 2-hydroxy-N-methoxy-N-methyl-2-phenylacetamide(143314-51-6)

Safety Data

• Hazardous Substances Data: 143314-51-6(Hazardous Substances Data)

Upstream product

• 4358-87-6 (RS)-methyl mandelate 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 611-71-2 MANDELIC ACID 
• 50916-31-9 2-hydroxy-2-phenylacetyl chloride 

Downstream Products

• 1190113-43-9 C₂₁H₂₈O₂Si 
• 1260146-50-6 (R)-1-hydroxy-1,4-diphenylbutan-2-one 
• 854461-19-1 1,4-diphenylbutane-1,2-dione 
• 1260146-52-8 (R)-1-hydroxy-3-methyl-1-phenylbutan-2-one 
• 7332-95-8 3-methyl-1-phenylbutane-1,2-dione 
• 23464-17-7 1,3-diphenylpropane-1,2-dione 
• 41049-36-9 1-hydroxy-1,3-diphenylpropan-2-one 
• 16183-45-2 1-hydroxy-1-phenylbutan-2-one 
• 37112-25-7 1-hydroxy-3-methyl-1-phenylbutan-2-one 
• 41049-36-9 1-hydroxy-1,3-diphenylacetone 
• 70187-14-3 1-hydroxy-1,4-diphenylbutan-2-one 
• 77302-16-0 (R)-1-hydroxy-1-phenylbutan-2-one 
• 3457-55-4 1-phenyl-1,2-butanedione 
• 5928-67-6 (S)-(+)-benzoin 

Relevant articles and documents

The Direct Conversion of α-Hydroxyketones to Alkynes

Alkynes are highly important functional groups in organic chemistry, both as part of target structures and as versatile synthetic intermediates. In this study, a protocol for the direct conversion of α-hydroxyketones to alkynes is reported. In combination with the variety of synthetic methods that generate the required starting materials by forming the central C-C bond, it enables a highly versatile fragment coupling approach toward alkynes. A broad scope for this novel transformation is shown alongside mechanistic insights. Furthermore, the utility of our protocol is demonstrated through its application in concert with varied α-hydroxyketone syntheses, giving access to a broad spectrum of alkynes.