3457-55-4

Basic information

• Product Name: 1-phenylbutane-1,2-dione
• CAS NO: 3457-55-4
• Molecular Formula: C₁₀H₁₀O₂
• Molecular Weight: 162.1852
• Mol File: 3457-55-4.mol
• Article Data: 40

Chemical Properties

• Boiling Point: 245.8°C at 760 mmHg
• Flash Point: 92.5°C
• Density: 1.073g/cm³
• Vapor Pressure: 0.0281mmHg at 25°C
• Refractive Index: 1.515
• CAS DataBase Reference: 1-phenylbutane-1,2-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenylbutane-1,2-dione(3457-55-4)
• EPA Substance Registry System: 1-phenylbutane-1,2-dione(3457-55-4)

Safety Data

• Hazardous Substances Data: 3457-55-4(Hazardous Substances Data)

Usage

General Description

1-Phenylbutane-1,2-dione, also known as dibenzoylmethane, is a chemical compound with the molecular formula C15H12O2. It is commonly used as a sunscreen ingredient due to its ability to absorb ultraviolet (UV) radiation. In addition to its UV-absorbing properties, 1-phenylbutane-1,2-dione also exhibits potential antioxidant activity, making it a popular ingredient in skincare products. This chemical compound has also been studied for its potential anti-inflammatory properties and is being researched for its potential use in the treatment of various skin conditions. Overall, 1-phenylbutane-1,2-dione is a versatile compound with significant potential applications in the cosmetic and pharmaceutical industries.

Upstream product

• 495-40-9 propiophenone 
• 16183-45-2 1-hydroxy-1-phenylbutan-2-one 
• 100-52-7 benzaldehyde 
• 877-35-0 2-bromo-1-phenylbutan-1-one 
• 143314-51-6 2-hydroxy-N-methoxy-N-methyl-2-phenylacetamide 
• 4358-87-6 (RS)-methyl mandelate 
• 611-71-2 MANDELIC ACID 
• 622-76-4 1-phenyl-1-butyne 
• 59417-06-0 1,4-dimethyl-2,3-dioxopiperazine 
• 16183-46-3 2-hydroxy-1-phenylbutan-1-one 
• 3375-31-3 palladium diacetate 
• 123-38-6 propionaldehyde 
• 95736-13-3 tert-Butyldimethyl[(1-ethyl-2-phenylethenyl)oxy]silane 
• 100-42-5 styrene 

Downstream Products

• 92-52-4 biphenyl 
• 100-52-7 benzaldehyde 
• 134-81-6 benzil 
• 65-85-0 benzoic acid 
• 93-58-3 benzoic acid methyl ester 
• 93-97-0 benzoic acid anhydride 
• 98-86-2 acetophenone 
• 130925-78-9 2-Benzyl-2-hydroxy-1-phenyl-butan-1-one 
• 130925-75-6 2-Hydroxy-1,2-diphenyl-pentan-3-one 
• 130925-77-8 2-Ethyl-2-hydroxy-1-phenyl-pent-4-en-1-one 
• 130925-74-5 4-Hydroxy-4-phenyl-hept-6-en-3-one 
• 139386-82-6 4-<1-(5-phenyl-2-thio-4-imidazolinyl)ethyl>-5-phenyl-4-imidazoline-2-thione 
• 139386-71-3 4-ethylene-1,3-dimethyl-5-phenyl-4-imidazoline-2-thione 
• 139386-70-2 1-<1-(1,3-dimethyl-5-phenyl-2-thio-1,2-dihydroimidazolyl)ethyl>-3-methylthiourea 

Relevant articles and documents

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Catalyst-Free and Transition-Metal-Free Approach to 1,2-Diketones via Aerobic Alkyne Oxidation

A catalyst-free and transition-metal-free method for the synthesis of 1,2-diketones from aerobic alkyne oxidation was reported. The oxidation of various internal alkynes, especially more challenging aryl-alkyl acetylenes, proceeded smoothly with inexpensive, easily handled, and commercially available potassium persulfate and an ambient air balloon, achieving the corresponding 1,2-diketones with up to 85% yields. Meanwhile, mechanistic studies indicated a radical process, and the two oxygen atoms in the 1,2-diketons were most likely from persulfate salts and molecular oxygen, respectively, rather than water.

Visible light promoted continuous flow photocyclization of 1,2-diketones

The continuous flow Norrish-Yang photocyclization of 1,2-diketones has been developed and used for the synthesis of a large number of functionalized 2-hydroxycyclobutanones, under blue light irradiation and employing acetone as a solvent. This eco-friendly procedure represents a valid alternative to the reactions carried out in batches thus reducing the reaction times, the formation of secondary products and simplifying the purification steps. The use of differently substituted diketone compounds has allowed us to obtain a wide range of 2 and 3-functionalized cyclobutanones, thus allowing the evaluation of the scope and limitations of this procedure.

ICl/AgNO3 Co-catalyzed radical oxidation of diaryl- A nd alkylarylalkynes into 1,2-diketones

A novel ICl/AgNO3 co-catalyzed radical oxidation of diaryl- A nd alkylarylalkynes into 1,2-diketones is reported. The reaction proceeded smoothly under mild conditions and generated 1,2-diketones in moderate to good yields with a good tolerance of functional groups. Furthermore, the obtained C4-(1,2-diketoaryl)isoxazoles could react smoothly with 1,2-diaminobenzene to form C4-(3-arylquinoxalin-2-yl)isoxazoles. At last, a new one-pot strategy for the synthesis of quinoxalines from 1,2-diphenylethynes and 1,2-diaminobenzene is also reported.