144106-03-6

Basic information

• Product Name: (Z)-2-(2-tolyl)-2-methoxyiminoacetic acid methyl ester
• Synonyms: (Z)-2-(2-tolyl)-2-methoxyiminoacetic acid methyl ester
• CAS NO: 144106-03-6
• Molecular Weight: 207.229
• Mol File: 144106-03-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (Z)-2-(2-tolyl)-2-methoxyiminoacetic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-2-(2-tolyl)-2-methoxyiminoacetic acid methyl ester(144106-03-6)
• EPA Substance Registry System: (Z)-2-(2-tolyl)-2-methoxyiminoacetic acid methyl ester(144106-03-6)

Safety Data

• Hazardous Substances Data: 144106-03-6(Hazardous Substances Data)

Upstream product

• 933-88-0 ortho-toluoyl chloride 
• 5955-73-7 2-methylbenzoyl cyanide 
• 34966-54-6 methyl 2-oxo-2-(o-tolyl)acetate 
• 593-56-6 N-methoxylamine hydrochloride 

Downstream Products

• 120974-97-2 methyl-(E)-2-(2-tolyl)-2-methoxyiminoacetate 
• 1462379-43-6 (E)-2-methoxyimino-2-(o-tolyl)acetic acid 
• 133409-72-0 methyl (E)-2-[2-(bromomethyl)phenyl]-2-(methoxyimino)acetate 
• 238410-27-0 enestroburin 

Relevant articles and documents

Synthesis and biological evaluation of kresoxim-methyl analogues as novel inhibitors of hypoxia-inducible factor (HIF)-1 accumulation in cancer cells

We designed and synthesized strobilurin analogues as hypoxia-inducible factor (HIF) inhibitors based on the molecular structure of kresoxim-methyl. Biological evaluation in human colorectal cancer HCT116 cells showed that most of the synthesized kresoxim-methyl analogues possessed moderate to potent inhibitory activity against hypoxia-induced HIF-1 transcriptional activation. Three candidates, compounds 11b, 11c, and 11d were identified as potent inhibitors against HIF-1 activation with IC50 values of 0.60–0.94?μM. Under hypoxic condition, compounds 11b, 11c, and 11d increased the intracellular oxygen contents, thereby attenuating the hypoxia-induced accumulation of HIF-1α protein.