34966-54-6

Basic information

• Product Name: methyl o-methyl phenyl glyoxylate
• Synonyms: methyl o-methyl phenyl glyoxylate;Methyl 2-(2-methylphenyl)-2-oxoacetate;Methyl 2-methylphenylglyoxylate;Methyl o-toluoylformate;methyl 2-oxo-2-o-tolylacetate;o-Tolylglyoxylic Acid Methyl Ester;2-Methyl-oxo-benzeneacetic acid methyl ester
• CAS NO: 34966-54-6
• Molecular Formula: C₁₀H₁₀O₃
• Molecular Weight: 178.18
• Mol File: 34966-54-6.mol
• Article Data: 28

Chemical Properties

• Boiling Point: 274℃
• Flash Point: 120℃
• Appearance: /
• Density: 1.133
• Vapor Pressure: 0.00563mmHg at 25°C
• Refractive Index: 1.516
• Solubility: DCM, Ethyl Acetate
• CAS DataBase Reference: methyl o-methyl phenyl glyoxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl o-methyl phenyl glyoxylate(34966-54-6)
• EPA Substance Registry System: methyl o-methyl phenyl glyoxylate(34966-54-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 34966-54-6(Hazardous Substances Data)

Usage

Description

Methyl o-methyl phenyl glyoxylate, also known as o-Tolylglyoxylic Acid Methyl Ester, is an organic compound that serves as a crucial intermediate in the chemical synthesis process. It is characterized by its functional groups and reactivity, which make it a valuable component in the production of various chemical products.

Uses

Used in Plant Protection Industry:
Methyl o-methyl phenyl glyoxylate is used as an intermediate in the synthesis of Trifloxystrobin (T778900) for its role in creating a broad-spectrum foliar fungicide. This fungicide is essential in plant protection, as it helps control a wide range of fungal diseases that can damage or destroy crops. The application of methyl o-methyl phenyl glyoxylate in this context is due to its ability to contribute to the development of an effective and reliable fungicide, ensuring the health and productivity of agricultural plants.

InChI:InChI=1/C10H10O3/c1-7-5-3-4-6-8(7)9(11)10(12)13-2/h3-6H,1-2H3

Upstream product

• 5955-73-7 2-methylbenzoyl cyanide 
• 553-90-2 Dimethyl oxalate 
• 95-46-5 2-methylphenyl bromide 
• 40851-62-5 methyl o-tolylacetate 
• 577-16-2 2-Methylacetophenone 
• 74-88-4 methyl iodide 
• 18166-02-4 N-trimethylsilylmethylamine 
• 124-38-9 carbon dioxide 
• 65284-33-5 (o-tolylcarbonyl)trimethylsilane 
• 22364-68-7 2-tolylmethylnitrile 
• 77062-83-0 methyl 2-hydroxy-2-(o-tolyl)acetate 
• 67-56-1 methanol 
• 1006432-80-9 C₁₁H₉F₃O₂ 
• 63440-60-8 2-(o-tolyl)-2-oxo-ethanale 

Downstream Products

• 1043605-47-5 2-hydroxy-2-o-tolylpropionic acid methyl ester 
• 120974-97-2 methyl-(E)-2-(2-tolyl)-2-methoxyiminoacetate 
• 144106-03-6 (Z)-2-(2-tolyl)-2-methoxyiminoacetic acid methyl ester 
• 1224978-68-0 (R)-methyl 2-cyano-2-(2-methylphenyl)-2-trimethylsiloxyacetate 
• 133409-72-0 methyl (E)-2-[2-(bromomethyl)phenyl]-2-(methoxyimino)acetate 
• 105182-38-5 (S)-2-hydroxy-2-(o-tolyl)acetic acid 
• 178983-17-0 C₁₀H₁₁NO₃ 

Relevant articles and documents

Unraveling two pathways for NHPI-mediated electrocatalytic oxidation reaction

Two pathways for N-hydroxyphthalimide (NHPI)-mediated electrocatalytic oxidation using phenylacetate derivatives as template substrates were first reported for benzylic C[sbnd]H oxidation to oxygenated and non-oxygenated products. DFT calculation indicates that the hydrogen-atom transfer (HAT) process between phthalimido-N-oxyl (PINO) and substrate is a rate-determined step. Aromatic α-keto esters and 2-((1,3-dioxoisoindolin-2-yl)oxy)-2-aryl acetate obtained by cross-coupling between benzylic radical and PINO can be selectively synthesized through controlling the concentration of PINO radical. This method provides a deep understanding for selective weak C[sbnd]H oxidation using NHPI as redox mediator.

Visible-Light-Induced Catalyst-Free Carboxylation of Acylsilanes with Carbon Dioxide

Intermolecular carbon-carbon bond formation between acylsilanes and carbon dioxide (CO2) was achieved by photoirradiation under catalyst-free conditions. In this reaction, siloxycarbenes generated by photoisomerization of the acylsilanes added to the C═O bond of CO2 to give α-ketocarboxylates, which underwent hydrolysis to afford α-ketocarboxylic derivatives in good yields. Control experiments suggest that the generated siloxycarbene is likely to be from the singlet state (S1) of the acylsilane and the addition to CO2 is not in a concerted manner.

Method for preparing spiro beta-lactam

The invention discloses a method for preparing spiro beta-lactam. The method comprises the following step: carrying out [2+1] cyclization reaction on beta-lactam and keto ester under the condition ofa phosphine catalyst to generate spiro beta-lactam. The