5955-73-7

Basic information

• Product Name: 2-METHYLBENZOYL CYANIDE
• Synonyms: 2-METHYLBENZOYL CYANIDE;OXO-O-TOLYL-ACETONITRILE;2-methyl phenyl glyoxylonitrile;Benzeneacetonitrile, 2-Methyl-a-oxo-
• CAS NO: 5955-73-7
• Molecular Formula: C₉H₇NO
• Molecular Weight: 145.16
• EINECS: 200-258-5
• Mol File: 5955-73-7.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 239.226 °C at 760 mmHg
• Flash Point: 98.481 °C
• Appearance: /
• Density: 1.111 g/cm³
• Vapor Pressure: 0.041mmHg at 25°C
• Refractive Index: 1.541
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-METHYLBENZOYL CYANIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYLBENZOYL CYANIDE(5955-73-7)
• EPA Substance Registry System: 2-METHYLBENZOYL CYANIDE(5955-73-7)

Safety Data

• Hazardous Substances Data: 5955-73-7(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

InChI:InChI=1/C9H7NO/c1-7-4-2-3-5-8(7)9(11)6-10/h2-5H,1H3

Upstream product

• 82128-96-9 2-trimethylsilyloxy-2-(2-methylphenyl)acetonitrile 
• 84452-03-9 Dichloro-o-tolyl-acetonitrile 
• 22364-68-7 2-tolylmethylnitrile 
• 85589-34-0 2-hydroxy-2-(2-methylphenyl)acetonitrile 
• 933-88-0 ortho-toluoyl chloride 
• 74-90-8 hydrogen cyanide 
• 773837-37-9 sodium cyanide 
• 118-90-1 ortho-methylbenzoic acid 
• 143-33-9 sodium cyanide 
• 1052175-57-1 C₉H₈BrN 
• 529-20-4 2-methylphenyl aldehyde 
• 151-50-8 potassium cyanide 
• 7677-24-9 trimethylsilyl cyanide 
• 544-92-3 copper(I) cyanide 

Downstream Products

• 62281-72-5 ethyl hydroxy(2-methylphenyl)acetate 
• 34966-54-6 methyl 2-oxo-2-(o-tolyl)acetate 
• 133409-72-0 methyl (E)-2-[2-(bromomethyl)phenyl]-2-(methoxyimino)acetate 
• 120974-97-2 methyl-(E)-2-(2-tolyl)-2-methoxyiminoacetate 
• 144106-03-6 (Z)-2-(2-tolyl)-2-methoxyiminoacetic acid methyl ester 

Relevant articles and documents

Preparation method of O-methylbenzoyl nitrile

The method comprises the following steps: firstly dissolving o-methylbenzoic acid in a toluene solvent, dropping the dimethyl sulfoxide to carry out reaction, and removing a small amount of unreacted dichlorosulphoxide at low temperature after the reactio

Acceptorless and Base-free Dehydrogenation of Cyanohydrin with (η6-Arene)halide(Bidentate Phosphine)ruthenium(II) Complex

Ruthenium-catalyzed dehydrogenation of cyanohydrins under acceptorless and base-free conditions was demonstrated for the first time in the synthesis of acyl cyanide. As opposed to the thermodynamically preferred elimination of hydrogen cyanide, the dehydrogenation of cyanohydrins could be kinetically controlled with ruthenium (II) bidentate phosphine complexes. The effects of the arene, phosphine ligands and counter anions were investigated in regard to catalytic activity and selectivity. Selective dehydrogenation can occur via β-hydride elimination with the experimentally observed [(alkoxide)Ru] complex. (Figure presented.).

Synthesis and biological evaluation of kresoxim-methyl analogues as novel inhibitors of hypoxia-inducible factor (HIF)-1 accumulation in cancer cells

We designed and synthesized strobilurin analogues as hypoxia-inducible factor (HIF) inhibitors based on the molecular structure of kresoxim-methyl. Biological evaluation in human colorectal cancer HCT116 cells showed that most of the synthesized kresoxim-methyl analogues possessed moderate to potent inhibitory activity against hypoxia-induced HIF-1 transcriptional activation. Three candidates, compounds 11b, 11c, and 11d were identified as potent inhibitors against HIF-1 activation with IC50 values of 0.60–0.94?μM. Under hypoxic condition, compounds 11b, 11c, and 11d increased the intracellular oxygen contents, thereby attenuating the hypoxia-induced accumulation of HIF-1α protein.