14432-16-7Relevant articles and documents
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Finger,Starr
, p. 2674 (1959)
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A 2 - chloro -4 - aminopyridine preparation method
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Paragraph 0016; 0019; 0021; 0023; 0025; 0028; 0030, (2019/05/28)
The invention belongs to the field of organic synthesis, in particular relates to a 2 - chloro - 4 - aminopyridine preparation method, comprises the following steps: (1) to 2 - chloro pyridine as raw materials, chloroform as solvent, under the action of the meta-chloroperoxybenzoic acid to produce 2 - chloro pyridine oxide; (2) 2 - chloro pyridine oxide by the concentrated nitric acid in concentrated sulfuric acid the acid produced by the reaction of a 2 - chloro - 4 - nitro pyridine nitrogen oxides; (3) 2 - chloro - 4 - nitro pyridine nitrogen oxide reduction is 2 - chloro - 4 - aminopyridine. The beneficial effect of the invention is: mild reaction conditions, is easy to operate, after treatment is simple, and easy to enlarge production, is extremely suitable for industrial production; good catalytic effect, high yield; low prices of raw materials, the production cost is low.
Design and synthesis of purine analogues as highly specific ligands for FcyB, a ubiquitous fungal nucleobase transporter
Lougiakis, Nikolaos,Gavriil, Efthymios-Spyridon,Kairis, Markelos,Sioupouli, Georgia,Lambrinidis, George,Benaki, Dimitra,Krypotou, Emilia,Mikros, Emmanuel,Marakos, Panagiotis,Pouli, Nicole,Diallinas, George
, p. 5941 - 5952 (2016/11/09)
In the course of our study on fungal purine transporters, a number of new 3-deazapurine analogues have been rationally designed, based on the interaction of purine substrates with the Aspergillus nidulans FcyB carrier, and synthesized following an effective synthetic procedure. Certain derivatives have been found to specifically inhibit FcyB-mediated [3H]-adenine uptake. Molecular simulations have been performed, suggesting that all active compounds interact with FcyB through the formation of hydrogen bonds with Asn163, while the insertion of hydrophobic fragments at position 9 and N6 of 3-deazaadenine enhanced the inhibition.