144539-79-7Relevant articles and documents
Partial synthesis of 14-deoxy-14-aminotriptolide
Kaloun, El Bachir,Long, Christophe,Molinier, Nicolas,Brel, Viviane,Cantagrel, Frédéric,Massiot, Georges
, p. 1895 - 1898 (2016)
Triptolide is a diterpene triepoxide isolated from Tripterygium wilfordii, a Chinese medicinal plant and possessing a wealth of biological activities. In order to produce more soluble derivatives of triptolide, its 14-amino analogue was prepared. Initial attempts at its preparation using classical displacements led to rearranged compounds and success was finally met using carefully controlled Borch conditions. 14-Deoxy-14-aminotriptolide was thus prepared for the first time and it was found 10 times less cytotoxic than the parent compound.
Semisynthesis of triptolide analogues: Effect of B-ring substituents on cytotoxic activities
Xu, Hongtao,Chen, Yi,Tang, Huanyu,Feng, Huijin,Li, Yuanchao
, p. 5671 - 5674 (2015/01/08)
A series of B-ring modified analogues of triptolide were synthesized and tested for their cytotoxicity against two human tumor cell lines (U251 and PC-3). From the current investigation, the structure-cytotoxic activity relationships of these analogues su
Efficient syntheis of the key intermediate triptophenolide methyl ether for the synthesis of(-)-triptolide
Zhou, Bing,Li, Xiaomei,Feng, Huijin,Li, Yuanchao
scheme or table, p. 5396 - 5401 (2010/08/19)
An efficient synthesis of triptophenolide methyl ether 4 from the readily available abietic acid 3 in nine steps is described and successfully applied to the synthesis of (-)-triptolide 1.The route is of characteristic of low cost, high yield and easy operation.In addition, every reaction in this route has been successfully scaled-up to a 100 g substrate level without loss of yield.
