146986-42-7Relevant articles and documents
Regioselective nucleophilic ring-opening reaction of chiral epoxyallyl alcohols: A ready access to the pyran core of macrolactin 3
Radha Krishna, Palakodety,Nomula, Rajesh,Rama Krishna, Kallaganti V.S.
, p. 3381 - 3383 (2014/06/09)
Herein we report the synthetic strategy towards the pyran core of macrolactin 3 via Sharpless epoxidation, titanium(IV) mediated regioselective ring-opening reaction of epoxyallyl alcohol/epoxy alcohol and oxa-Michael addition as the key steps.
Synthesis of Entecavir (BMS-200475)
Zhou, Bing,Li, Yuanchao
, p. 502 - 504 (2012/02/02)
A synthesis of Entecavir (BMS-200475) was achieved starting from 1,3-propanediol in 15 steps and 23.4% overall yield. A unique feature of the synthetic route is that the five-membered carbocyclic core is installed by an intramolecular nitrile oxide cycloaddition (INOC) reaction and the guanine moiety is introduced by a Mitsunobu reaction. The route is characteristic of low cost, high yield and easy operation.
InCl3-mediated intramolecular Friedel-Crafts-type cyclization and its application to construct the [6-7-5-6] tetracyclic scaffold of liphagal
Jiang, Hao,Tian, Lufeng,Li, Zhentao,Liu, Qi,Li, Chuangchuang,Yao, Xinsheng,Yang, Zhen
experimental part, p. 36 - 42 (2012/03/22)
A unified strategy toward the construction of the [5.7.6]tricyclic skeleton of liphagal is reported, featuring InCl3-mediated intramolecular Friedel-Crafts-type cyclization.