154471-65-5

Basic information

• Product Name: 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE
• Synonyms: 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE;1-Methyl-3-trifluoromethyl-1H-pyrazole ,97%;1-Methyl-3-(trifluoroMethyl)pyrazole;1H-Pyrazole, 1-methyl-3-(trifluoromethyl)-
• CAS NO: 154471-65-5
• Molecular Formula: C₅H₅F₃N₂
• Molecular Weight: 150.1
• EINECS: 1312995-182-4
• Mol File: 154471-65-5.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 137.721 °C at 760 mmHg
• Flash Point: 37.093 °C
• Appearance: /
• Density: 1.328 g/cm³
• Vapor Pressure: 8.634mmHg at 25°C
• Refractive Index: 1.444
• Storage Temp.: 2-8°C
• PKA: -0.71±0.10(Predicted)
• CAS DataBase Reference: 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE(154471-65-5)
• EPA Substance Registry System: 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE(154471-65-5)

Safety Data

• Safety Statements: 22-24/25
• Hazardous Substances Data: 154471-65-5(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

InChI:InChI=1/C5H5F3N2/c1-10-3-2-4(9-10)5(6,7)8/h2-3H,1H3

Upstream product

• 59938-06-6 4-ethoxy-1,1,1-trifluoro-3-butene-2-one 
• 60-34-4 methylhydrazine 
• 59938-06-6 (E)-4-Ethoxy-1,1,1-trifluoro-3-buten-2-one 
• 302-15-8 methylhydrazine sulfuric acid 
• 20154-03-4 3-(trifluoromethyl)pyrazole 
• 74-88-4 methyl iodide 

Downstream Products

• 129768-24-7 1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carbonyl chloride 
• 149978-43-8 1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-amine 
• 839714-54-4 4-bromo-5-(2-methoxy-5-nitro-phenyl)-1-methyl-3-trifluoromethyl-1H-pyrazole 
• 839714-57-7 4-chloro-5-(2-methoxy-5-nitro-phenyl)-1-methyl-3-trifluoromethyl-1H-pyrazole 
• 839714-56-6 3-(4-chloro-2-methyl-5-trifluoromethyl-2H-pyrazol-3-yl)-4-methoxy-phenylamine 
• 839714-53-3 3-(4-bromo-2-methyl-5-trifluoromethyl-2H-pyrazol-3-yl)-4-methoxy-phenylamine. 
• 839714-55-5 5-(2-methoxy-5-nitro-phenyl)-1-methyl-3-trifluoromethyl-1H-pyrazole 
• 839714-58-8 4-methoxy-3-(2-methyl-5-trifluoromethyl-2H-pyrazol-3-yl)-phenylamine 
• 1355631-31-0 N-(methylsulfonyl)-4-({4-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]phenoxy}methyl)benzamide diethylamine salt 
• 1355636-66-6 4-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]phenol 
• 515120-72-6 1-methyl-3-(trifluoromethyl)-N-[4-(pyrrolidinylsulfonyl)phenyl]-1H-pyrazole-5-carboxamide 
• 128694-63-3 1-methyl-3-(trifluoromethyl)pyrazole-5-carboxylic acid 
• 344591-91-9 [1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]boronic acid 
• 497833-05-3 4-bromo-1-methyl-3-trifluoromethyl-5-pyrazolecarboxylic acid 

Relevant articles and documents

Palladium-catalyzed Aerobic Benzannulation of Pyrazoles with Alkynes

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Method for preparing heterocyclic small molecule compound

The invention belongs to the field of medical chemistry, particularly belongs to the field of organic synthesis in medical chemistry, and more particularly relates to a preparation method of a heterocyclic small molecule compound. According to the preparation method, vinyl ethyl ether is used as a raw material, and a target compound, trifluoromethylpyrazole borate, is obtained through four steps.The product is an important building block in drug research, development and synthesis, and the industrial preparation method of the product can provide guarantee for subsequent in-depth research anddevelopment. Therefore, the invention is beneficial to research and development of related drug synthesis.

4-Methylsulfonyl-Substituted Piperidine Urea Compounds

The present invention provides novel 4-methylsulphone-substituted piperidine urea compounds that are useful for the treatment of dilated cardiomyopathy (DCM) and conditions associated with left and/or right ventricular systolic dysfunction or systolic reserve. The synthesis and characterization of the compounds is described, as well as methods for treating DCM and other forms of heart disease.