15674-78-9

Basic information

• Product Name: ethyl 2-bromo-2-p-tolylacetate
• Synonyms: ethyl 2-bromo-2-p-tolylacetate
• CAS NO: 15674-78-9
• Molecular Weight: 257.127
• Mol File: 15674-78-9.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: ethyl 2-bromo-2-p-tolylacetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-bromo-2-p-tolylacetate(15674-78-9)
• EPA Substance Registry System: ethyl 2-bromo-2-p-tolylacetate(15674-78-9)

Safety Data

• Hazardous Substances Data: 15674-78-9(Hazardous Substances Data)

Upstream product

• 14062-19-2 p-tolylacetic acid ethyl ester 
• 18584-23-1 hydroxy-p-tolyl-acetic acid ethyl ester 
• 5720-05-8 4-methylphenylboronic acid 
• 105-36-2 ethyl bromoacetate 
• 66985-49-7 2-(4-methylphenyl)-2-(trimethylsilyloxy)acetonitrile 
• 104-87-0 4-methyl-benzaldehyde 
• 64-17-5 ethanol 
• 622-47-9 4-tolylacetic acid 
• 27668-90-2 p-methylphenyldiazoacetic acid ethyl ester 
• 2826-25-7 2-(4-methylbenzylidene)malononitrile 
• 1019019-27-2 2-Hydroxy-2-p-tolyl-acetimidic acid ethyl ester 
• 4815-10-5 2-hydroxy-2-(4-methylphenyl)acetonitrile 
• 18584-20-8 4-methylmandelic acid 
• 25297-16-9 2-bromo-2-(p-tolyl)acetic acid 

Downstream Products

• 116544-54-8 (2-Benzoyl-4-chloro-phenoxy)-p-tolyl-acetic acid ethyl ester 
• 116544-53-7 (2-Benzoyl-phenoxy)-p-tolyl-acetic acid ethyl ester 
• 116544-56-0 (2-Benzoyl-4,6-dimethyl-phenoxy)-p-tolyl-acetic acid ethyl ester 
• 116544-57-1 (6-Benzoyl-2,3-dimethyl-phenoxy)-p-tolyl-acetic acid ethyl ester 
• 116544-55-9 (2-Benzoyl-4-methyl-phenoxy)-p-tolyl-acetic acid ethyl ester 
• 190672-14-1 ethyl 4-methylphenyl(phenylsulfonyl)acetate 
• 354759-01-6 (+/-)-α-[3[2(1H-pyrrol-yl)pyridyl]oxy]-p-tolylacetic acid ethyl ester 
• 181304-22-3 (2-Pyrrol-1-yl-phenoxy)-p-tolyl-acetic acid 
• 249741-92-2 (+/-)-6-p-Tolylpyrrolo[2,1-d][1,5]benzoxazepin-7(6H)-one 
• 1345693-49-3 N,N-dibenzyl-2-((tert-butyl)dimethylsilyloxy)-2-ethoxy-1-(p-tolyl)ethenamine 
• 1345693-71-1 ethyl 2-(dibenzylamino)-2-(p-tolyl)butanoate 

Relevant articles and documents

Synthesis of isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine: two new ring systems of pharmaceutical interest

Abstract Two new ring systems, isoindolo[1,4]benzoxazinone and isoindolo[1,5]benzoxazepine, were conveniently synthesized through cyclization of suitably substituted isoindole derivatives. Some of the new compounds exhibited antiproliferative activity aga

Synthesis of α,α-disubstituted α-amino esters: Nucleophilic addition to iminium salts generated from amino ketene silyl acetals

Alkoxycarbonyl iminium species are prepared easily by the oxidation of tetrasubstituted amino ketene silyl acetals, and subsequent nucleophilic addition of Grignard reagents to the iminium salts gives α,α- disubstituted α-amino ester derivatives in moderate to good yields, in which aryl and ethynyl substituents are readily introduced.

Lipase-catalyzed enantioselective transesterification toward esters of 2-bromo-tolylacetic acids

Lipases from Candida antarctica, Pseudomonas cepacia and Rhizomucor miehei were tested in the resolution of seven racemic substrates belonging to the (RS)-2-bromo tolyl acetate ester category, but differing either in the position of the methyl substituent on the acyl part of the aromatic ring, or in the structure of the alkyl group. Lipase-catalyzed kinetic resolution via transesterification reaction between the ester and octanol in octane revealed that, of the three enzymes tested, P. cepacia lipase is the most efficient for resolution of the various racemates, with R-enantiopreference. In addition, the position of the methyl substituent was found to play a key role in governing the enantioselectivity of the reaction. Using P. cepacia lipase and 2-bromo-m/p-tolyl- or 2-bromophenylacetic acid esters E-values of 6.