15833-61-1

Basic information

• Product Name: TETRAHYDRO-3-FURANMETHANOL
• Synonyms: Tetrahydro-3-furanylmethanol;(TETRAHYDROFURAN-3-YL)METHANOL;TETRAHYDRO-3-FURANMETHANOL;RARECHEM AL BD 0888;3-Hydroxymethyltetrahydrofuran;3-Hydroxymethyl-THF;Tetrahydrofuran-3-ylmetha...;(3-Oxolanyl)Methanol
• CAS NO: 15833-61-1
• Molecular Formula: C₅H₁₀O₂
• Molecular Weight: 102.1317
• EINECS: 1806241-263-5
• Product Categories: API intermediates;Building Blocks;Furans;Heterocyclic Building Blocks
• Mol File: 15833-61-1.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 76-77 °C4 mm Hg(lit.)
• Flash Point: 208 °F
• Appearance: /
• Density: 1.061 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0899mmHg at 25°C
• Refractive Index: n20/D 1.456(lit.)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 14.81±0.10(Predicted)
• CAS DataBase Reference: TETRAHYDRO-3-FURANMETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: TETRAHYDRO-3-FURANMETHANOL(15833-61-1)
• EPA Substance Registry System: TETRAHYDRO-3-FURANMETHANOL(15833-61-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 15833-61-1(Hazardous Substances Data)

Usage

Description

TETRAHYDRO-3-FURANMETHANOL, also known as THFM, is a colorless viscous liquid that is primarily formed during the hydrolysis of 1,3-dioxolane compounds. It is an organic compound with a unique structure that consists of a tetrahydrofuran ring and a hydroxymethyl group. Due to its chemical properties and structure, THFM has potential applications in various industries.

Uses

Used in Pharmaceutical Industry:
TETRAHYDRO-3-FURANMETHANOL is used as an intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a versatile building block in the development of new drugs, particularly those targeting specific biological pathways.
Used in Chemical Synthesis:
TETRAHYDRO-3-FURANMETHANOL is used as a key intermediate in the synthesis of various organic compounds, including specialty chemicals, agrochemicals, and other fine chemicals. Its ability to form a tetrahydrofuran ring makes it a valuable component in the creation of complex molecular structures.
Used in Polymer Industry:
TETRAHYDRO-3-FURANMETHANOL is used as a monomer for the production of polymers with specific properties. The incorporation of THFM into polymer chains can result in materials with enhanced characteristics, such as improved mechanical strength, thermal stability, or chemical resistance.
Used in Cosmetics Industry:
TETRAHYDRO-3-FURANMETHANOL is used as a component in the formulation of cosmetics and personal care products. Its compatibility with various ingredients and ability to improve the texture and consistency of formulations make it a valuable addition to the cosmetics industry.
Used in Flavor and Fragrance Industry:
TETRAHYDRO-3-FURANMETHANOL is used as a building block for the creation of unique fragrances and flavors. Its ability to contribute to the overall sensory profile of a product makes it an important component in the development of novel scents and tastes.

InChI:InChI=1/C5H10O2/c6-3-5-1-2-7-4-5/h5-6H,1-4H2

Upstream product

• 89364-31-8 3-tetrahydrofuroic acid 
• 79710-86-4 tetrahydrofuran-3-carboxaldehyde 
• 67-63-0 isopropyl alcohol 
• 18132-98-4 α-hydroxymethyl-γ-butyrolactone 
• 109-99-9 tetrahydrofuran 
• 67-56-1 methanol 
• 5472-38-8 diethyl 2-formylbutanedioate 
• 4360-91-2 α-carboxy-γ-butyrolactone 
• 6482-32-2 2-(hydroxymethyl)butane-1,4-diol 
• 63972-17-8 1,3-diethyl 2-(2-hydroxyethyl)propanedioate 
• 1191-99-7 2,3-dihydro-2H-furan 
• 201230-82-2 carbon monoxide 
• 1708-29-8 2,5-dihydrofuran 
• 488-93-7 3-Furoic acid 

Downstream Products

• 15833-63-3 (tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate 
• 13423-15-9 3-methyltetrahydrofuran 
• 64190-48-3 dihydro-4-methyl-2(3H)-furanone 
• 1679-47-6 3-methyltetrahydro-2-furanone 
• 160232-34-8 4-nitrophenyl tetrahydrofuran-3-ylmethyl carbonate 
• 667402-35-9 [1-(2-{4-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-2-oxo-1,2-dihydro-pyridin-3-yl}-7-methyl-3H-benzoimidazol-5-yl)-piperidin-4-yl]-carbamic acid tetrahydro-furan-3-ylmethyl ester 
• 1093205-23-2 2-amino-6-((tetrahydrofuran-3-yl)methoxy)benzonitrile 
• 1093205-24-3 2-nitro-6-((tetrahydrofuran-3-yl)methoxy)benzonitrile 
• 165253-31-6 (tetrahydro-3-furanyl)methylamine 
• 89364-31-8 3-tetrahydrofuroic acid 
• 127047-77-2 4-acetoxy-3-(acetoxymethyl)-1-iodobutane 
• 96-47-9 2-methyltetrahydrofuran 
• 930-27-8 3-methylfuran 

Relevant articles and documents

3-(5-METHOXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF

The present disclosure relates to compounds of formula (I') and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.

Insecticide dinotefuran intermediate 3 - hydroxy methyl tetrahydrofuran synthetic method

The invention discloses a synthetic method of pesticide dinotefuran intermediate 3-hydroxymethyl tetrahydrofuran, and the synthetic method is as follows: reacting compound succinic acid dialkyl ester with formic acid alkyl ester in the presence of a strong alkali to obtain a compound III, then obtaining a compound II by a reduction reaction, finally, in the presence of an acid catalyst, obtaining a compound shown as formula I by a dehydration cyclization reaction, and R or R ' respectively independently represents C1-5 alkyl. The synthetic method is low in raw material cost, simple in reaction operation, less in pollution, high in yield of each step, 99% in the yield of the reducing step, and suitable for industrial production.

Preparation method of tetrahydro-3-furanmethanol

The invention relates to the field of preparation of insecticides, in particular to a preparation method of tetrahydro-3-furanmethanol. The method comprises the steps as follows: 13.6 g of sodium ethoxide and 0.5 g of sodium iodide are dissolved in 120 mL of absolute ethyl alcohol, 32 g of diethyl malonate is dropwise added in an ice-water bath, the temperature is controlled at 20 DEG C or below,stirring is performed continuously for 1 h after addition, then 30.3 g of ethyl bromoacetate is slowly added, the temperature is increased to 50-60 DEG C after addition, stirring is performed for about 8 h, ethyl bromoacetate is detected to be used up through gas chromatography, a heating reaction is stopped, the system is cooled to the room temperature, 10 mL of a saturated ammonium chloride solution is added with stirring, the system is adjusted to be neutral or slightly acid, solvent ethyl alcohol is evaporated, residues are dissolved in 100 mL of water and 100 mL of ethyl acetate for extraction, solution separation is performed, an organic phase is separated, the solvent ethyl acetate is removed from the organic phase, reduced pressure distillation is performed through an oil pump, andthe first fraction point, namely, a triethyl 1,1,2-ethanetricarboxylate product, is collected. The process is simple, safety in actual production is guaranteed, and the product with higher yield is obtained.