159533-68-3

Basic information

• Product Name: 1-(5-BROMOPYRIDIN-2-YL)-ETHANOL
• Synonyms: 1-(5-BROMOPYRIDIN-2-YL)-ETHANOL;2-Pyridinemethanol,5-bromo-α-methyl-
• CAS NO: 159533-68-3
• Molecular Formula: C7H8BrNO
• Molecular Weight: 202.05
• Product Categories: pharmacetical
• Mol File: 159533-68-3.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 274.4°Cat760mmHg
• Flash Point: 119.8°C
• Appearance: /
• Density: 1.555g/cm³
• Vapor Pressure: 0.00263mmHg at 25°C
• Refractive Index: 1.578
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 1-(5-BROMOPYRIDIN-2-YL)-ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-BROMOPYRIDIN-2-YL)-ETHANOL(159533-68-3)
• EPA Substance Registry System: 1-(5-BROMOPYRIDIN-2-YL)-ETHANOL(159533-68-3)

Safety Data

• Hazardous Substances Data: 159533-68-3(Hazardous Substances Data)

Usage

General Description

1-(5-Bromopyridin-2-yl)-ethanol is a chemical compound with the molecular formula C7H8BrNO. It is a derivative of pyridine, a six-membered aromatic ring with one nitrogen atom. The compound contains a bromine atom attached to the 5th position of the pyridine ring and an ethanol group attached to the carbon adjacent to the nitrogen atom. 1-(5-Bromopyridin-2-yl)-ethanol is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It is also used as an intermediate in the production of other organic compounds. The chemical's properties and applications make it an important component in the field of organic chemistry and drug development.

InChI:InChI=1/C7H8BrNO/c1-5(10)7-3-2-6(8)4-9-7/h2-5,10H,1H3

Upstream product

• 159533-68-3 2-(1-hydroxyethyl)-5-bromopyridine 
• 31181-90-5 5-bromo-pyridine-2-carbaldehyde 
• 75-16-1 methylmagnesium bromide 
• 214701-49-2 1-(5-bromopyridin-2-yl)ethanone 
• 223463-13-6 2-iodo-5-bromopyridine 
• 75-07-0 acetaldehyde 
• 845305-87-5 5-bromo-2-(N-methylaminocarbonyl)pyridine 
• 30766-11-1 5-bromoisonicotinic acid 

Downstream Products

• 159533-68-3 (1R)-1-(5-bromopyridin-2-yl)ethanol 
• 159533-68-3 (1S)-1-(5-bromopyridin-2-yl)ethanol 
• 870694-29-4 2-bromo-1-(5-bromopyridin-2-yl)ethanone hydrobromide 
• 953780-20-6 (R)-1-(5-bromopyridin-2-yl)ethanamine 

Relevant articles and documents

Asymmetric Hydroboration of Heteroaryl Ketones by Aluminum Catalysis

A series of methyl aluminum complexes bearing chiral biphenol-type ligands were found to be highly active catalysts in the asymmetric reduction of heterocyclic ketones (S/C = 100-500, ee up to 99%). The protocol is suitable for a wide range of substrates and has a high tolerance to functional groups. The formed 2-heterocyclic-alcohols are valuable building blocks in drug discovery or can be used as ligands in asymmetric catalysis. Isolation and comprehensive characterization of the reaction intermediates support a catalysis cycle proposed by DFT calculations.

CONDENSED IMIDAZOLE DERIVATIVES SUBSTITUTED BY TERTIARY HYDROXY GROUPS AS PI3K-GAMMA INHIBITORS

This application relates to compounds of Formula (I): or pharmaceutically acceptable salts thereof, which are inhibitors of PI3K-y which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

ACETYLENIC MICROBIOCIDES

Compounds of formula (I), wherein the other substituents HetAr, A', R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined in claim 1, and their use in compositions and methods for the control and/or prevention of microbial infection, particularly fungal infection, in plants and to processes for the preparation of these compounds.