162809-96-3Relevant articles and documents
Biologically Active Taxane Analogs and Methods of Treatment
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Page/Page column 9; sheet 4, (2008/12/08)
The present application relates to new taxane analogs, pharmaceutical compositions comprising such analogs and methods of treating cancer comprising such compositions. The compounds according to the present application have the general formula: wherein R
The chemistry of the taxane diterpene: Stereoselective reductions of taxanes
Georg, Gunda I.,Harriman, Geraldine C. B.,Datta, Apurba,Ali, Syed,Cheruvallath, Zacharia,Dutta, Dinah,Vander Velde, David G.,Himes, Richard H.
, p. 8926 - 8934 (2007/10/03)
Stereoselective reductions of taxanes are detailed. Chelation- controlled reductions employing SmI2 are described for the stereoselective reduction of the 9-keto functionality of the diterpene moiety of several taxanes. In all cases the 9β-hydr