170902-80-4 Usage
Description
(2S,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine, also known as Fosaprepitant Morpholine, is an impurity of Fosaprepitant (F727300). Fosaprepitant is a selective neurokinin-1 (NK-1) receptor antagonist and is used as an antiemetic drug. It is a prodrug of Aprepitant (A729800), which is also an NK-1 receptor antagonist.
Uses
Used in Pharmaceutical Industry:
(2S,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine is used as an impurity in the production of Fosaprepitant (F727300) for its role as a selective neurokinin-1 (NK-1) receptor antagonist. This application is important because it helps in the development and formulation of antiemetic drugs, which are crucial for managing nausea and vomiting associated with various medical conditions and treatments.
Additionally, as an impurity in the production of Aprepitant (A729800), it contributes to the development of another NK-1 receptor antagonist, further expanding the range of antiemetic options available for medical use.
Check Digit Verification of cas no
The CAS Registry Mumber 170902-80-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,0,9,0 and 2 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 170902-80:
(8*1)+(7*7)+(6*0)+(5*9)+(4*0)+(3*2)+(2*8)+(1*0)=124
124 % 10 = 4
So 170902-80-4 is a valid CAS Registry Number.
170902-80-4Relevant articles and documents
Synthesis of all enantiomerically pure diastereomers of aprepitant
Gangula, Srinivas,Elati, Chandrashekhar R.,Mudunuru, Satish Varma,Nardela, Anitha,Dongamanti, Ashok,Bhattacharya, Apurba,Bandichhor, Rakeshwar
experimental part, p. 2254 - 2268 (2010/09/11)
Syntheses of all eight enantiomerically pure diastereomers of aprepitant and assignment of absolute configuration at newly generated stereocenters by NMR and X-ray crystallographic analysis were achieved. Copyrigh
