172822-28-5 Usage
Description
Aprepitant, also known as A729800, is a novel selective neurokinin-1 (NK-1) receptor antagonist. It is primarily used as an antiemetic and is an impurity in the synthesis of Aprepitant. Aprepitant is metabolized primarily by the CYP3A4 enzyme, with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. It is also a useful synthetic intermediate in the synthesis of morpholine tachykinin receptor antagonist prodrugs.
Uses
Used in Pharmaceutical Industry:
Aprepitant is used as an antiemetic agent for the treatment of nausea and vomiting associated with chemotherapy, radiotherapy, and postoperative recovery. It works by blocking the action of substance P, a neurotransmitter involved in the vomiting reflex, thereby reducing the severity and frequency of emesis.
Used in Research and Development:
(2S,3S,1’R)-Aprepitant is used as a synthetic intermediate in the development of morpholine tachykinin receptor antagonist prodrugs. These prodrugs have the potential to be more effective and safer alternatives to existing antiemetic medications, offering improved treatment options for patients experiencing nausea and vomiting due to various medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 172822-28-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,2,8,2 and 2 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 172822-28:
(8*1)+(7*7)+(6*2)+(5*8)+(4*2)+(3*2)+(2*2)+(1*8)=135
135 % 10 = 5
So 172822-28-5 is a valid CAS Registry Number.
172822-28-5Relevant articles and documents
Synthesis of all enantiomerically pure diastereomers of aprepitant
Gangula, Srinivas,Elati, Chandrashekhar R.,Mudunuru, Satish Varma,Nardela, Anitha,Dongamanti, Ashok,Bhattacharya, Apurba,Bandichhor, Rakeshwar
experimental part, p. 2254 - 2268 (2010/09/11)
Syntheses of all eight enantiomerically pure diastereomers of aprepitant and assignment of absolute configuration at newly generated stereocenters by NMR and X-ray crystallographic analysis were achieved. Copyrigh
