17193-31-6

Basic information

• Product Name: H-DL-Phe-NH2
• Synonyms: DL-Phenylalanine amide
• CAS NO: 17193-31-6
• Molecular Formula: C₉H₁₂N₂O
• Molecular Weight: 164.2044
• Mol File: 17193-31-6.mol
• Article Data: 31

Chemical Properties

• Boiling Point: 356.9 °C at 760 mmHg
• Flash Point: 169.7 °C
• Appearance: /
• Density: 1.143 g/cm³
• Vapor Pressure: 2.83E-05mmHg at 25°C
• Refractive Index: 1.575
• CAS DataBase Reference: H-DL-Phe-NH2(CAS DataBase Reference)
• NIST Chemistry Reference: H-DL-Phe-NH2(17193-31-6)
• EPA Substance Registry System: H-DL-Phe-NH2(17193-31-6)

Safety Data

• Hazardous Substances Data: 17193-31-6(Hazardous Substances Data)

Usage

General Description

H-DL-Phe-NH2, also known as D,L-phenylalanine amide, is a chemical compound consisting of the amino acid phenylalanine linked to an amine group. It is a synthetic analog of the natural amino acid phenylalanine. H-DL-Phe-NH2 is often used in research and pharmaceutical development for its potential therapeutic properties, such as its ability to act on the central nervous system. Additionally, H-DL-Phe-NH2 has been studied for its role in pain management and mood stabilization. It is commonly used in the scientific community as a tool to study various biological processes and pathways related to phenylalanine metabolism and neurotransmitter regulation. Overall, H-DL-Phe-NH2 is an important chemical that has potential applications in both basic research and pharmaceutical drug development.

InChI:InChI=1/C9H12N2O/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H2,11,12)/t8-/m0/s1

Upstream product

• 583-47-1 4-benzyl-oxazolidine-2,5-dione 
• 55379-75-4 2-amino-3-phenylpropanenitrile 
• 79559-52-7 3-phenyl-aziridine-2-carboxylic acid amide 
• 1795-96-6 phenylalanine ethyl ester 
• 7664-41-7 ammonia 
• 5241-58-7 L-Phenylalanine amide 
• 129095-62-1 (R)-tert-butyl (1-amino-1-oxo-3-phenylpropan-2-yl)carbamate 
• 18942-49-9 Boc-D-Phe-OH 
• 13250-12-9 (R)-sec-butylamine 
• 513-49-5 (S)-2-aminobutane 
• 71666-94-9 (R)-2-amino-3-phenylpropanamide hydrochloride 
• 2448-45-5 Cbz-D-Phe 
• 673-06-3 D-(R)-phenylalanine 
• 155385-80-1 (-)-1-(2-phenyl-ethylideneamino)-2R-methyl-5R-(1-methylethenyl)cyclohexane-1R,3R-dicarbonitrile 

Downstream Products

• 127479-01-0 benzyl-5 piperazinetrione-2,3,6 
• 5933-69-7 4-benzyl-[1,2,5]thiadiazol-3-ol 
• 65732-65-2 2-(2-Nitro-phenylsulfanylamino)-3-phenyl-propionamide 
• 74822-65-4 (R)-(+)-1,2-diamino-3-phenylpropane dihydrochloride 
• 63-91-2 L-phenylalanine 
• 5241-58-7 L-Phenylalanine amide 
• 673-06-3 D-(R)-phenylalanine 
• 5241-58-7 D-Phenylalaninamide 
• 153651-14-0 N²,N²-dimethyl-L-phenylalaninamide 
• 129095-62-1 (R)-tert-butyl (1-amino-1-oxo-3-phenylpropan-2-yl)carbamate 
• 1350980-62-9 N-(1-oxyl-4'-demethyl-4-deoxypodophyllic)-D-phenylalanine amide 
• 5426-73-3 2-amino-N,3-diphenylpropanamide 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 74822-73-4 (R)-2,4-Dibenzyl-4,5-dihydro-1H-imidazole 

Relevant articles and documents

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Mapping the s1 and s1’ subsites of cysteine proteases with new dipeptidyl nitrile inhibitors as trypanocidal agents

The cysteine protease cruzipain is considered to be a validated target for therapeutic intervention in the treatment of Chagas disease. A series of 26 new compounds were designed, synthesized, and tested against the recombinant cruzain (Cz) to map its S1/S1′ subsites. The same series was evaluated on a panel of four human cysteine proteases (CatB, CatK, CatL, CatS) and Leishmania mexicana CPB, which is a potential target for the treatment of cutaneous leishmaniasis. The synthesized compounds are dipeptidyl nitriles designed based on the most promising combinations of different moieties in P1 (ten), P2 (six), and P3 (four different building blocks). Eight compounds exhibited a Ki smaller than 20.0 nM for Cz, whereas three compounds met these criteria for LmCPB. Three inhibitors had an EC50 value of ca. 4.0 μM, thus being equipotent to benznidazole according to the antitrypanosomal effects. Our mapping approach and the respective structure-activity relationships provide insights into the specific ligand-target interactions for therapeutically relevant cysteine proteases.

Efficient Hydration of Nitriles Promoted by Gallic Acid Derived from Renewable Bioresources

An efficient gallic acid promoted nitriles hydration at room temperature with ethanol/water as a solvent has been developed. The present protocol offers a wide range of amides in moderate to good yields. Moreover, galla chinensis extract can serve as the promoter to perform the hydration, which also shows the potential utilization of natural feedstocks.