1735-89-3 Usage
Description
6-TRIFLUOROMETHYLOXINDOLE, also known as 6-(Trifluoromethyl)indolin-2-one, is an organic compound that features a trifluoromethyl group attached to an oxindole core. This unique structure endows it with specific chemical properties, making it a valuable intermediate in the synthesis of various pharmaceuticals and bioactive molecules.
Uses
Used in Pharmaceutical Industry:
6-TRIFLUOROMETHYLOXINDOLE is used as a key intermediate in the synthesis of oxindole derivatives, which are known for their potential as neuronal death inhibitors. These derivatives have therapeutic applications in the treatment of neurodegenerative diseases, where they can help protect neurons from damage and death, thereby slowing down disease progression.
In the preparation of these oxindole derivatives, 6-TRIFLUOROMETHYLOXINDOLE serves as a building block that can be further modified and functionalized to develop new drugs with improved efficacy and selectivity. Its unique trifluoromethyl group also contributes to the overall pharmacokinetic properties of the resulting compounds, potentially enhancing their stability, bioavailability, and target engagement.
Overall, 6-TRIFLUOROMETHYLOXINDOLE plays a crucial role in the development of novel therapeutic agents for the treatment of neurodegenerative disorders, offering a promising avenue for research and drug discovery in the pharmaceutical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 1735-89-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,7,3 and 5 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1735-89:
(6*1)+(5*7)+(4*3)+(3*5)+(2*8)+(1*9)=93
93 % 10 = 3
So 1735-89-3 is a valid CAS Registry Number.
InChI:InChI=1/C9H6F3NO/c10-9(11,12)6-2-1-5-3-8(14)13-7(5)4-6/h1-2,4H,3H2,(H,13,14)
1735-89-3Relevant articles and documents
A safe and selective method for reduction of 2-nitrophenylacetic acid systems to N-aryl hydroxamic acids using continuous flow hydrogenation
Ichire, Ogar,Jans, Petra,Parfenov, Galina,Dounay, Amy B.
, p. 582 - 585 (2017/01/16)
The cyclic hydroxamic acid functional group is critical to the biological activity of numerous natural products and drug candidates. Efficient, reliable, and green synthetic methods to produce cyclic hydroxamic acids are needed. Herein, flow hydrogenation has been explored as a novel approach toward achieving the selective partial reduction of 2-nitrophenylacetic acid to 1-hydroxyindolin-2-one. The bidentate ligand, 1,10-phenanthroline, has been identified as a unique inhibitor for modulating product selectivity in this Pt/C-catalyzed process. Under the newly optimized reaction conditions, the targeted hydroxamic acid is produced with high selectivity (49:1) over the lactam by-product. The scope of the reaction is demonstrated for a variety of 2-nitrophenylacetic acid derivatives.
SYNTHESIS OF THROMBOPOIETIN ACTIVITY MODULATING COMPOUNDS
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Page/Page column 49-50, (2008/06/13)
Disclosed herein are various methods for synthesizing compounds that modulate thrombopoietin activity. Also disclosed are intermediates useful for the preparation of these compounds.
3-(PIPERAZINYLBENZYLIDENYL)-2-INDOLINONE COMPOUNDS AND DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS
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, (2008/06/13)
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