184586-78-5

Basic information

• Product Name: (1S,2S,3R,4S,5R,7S,8S,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-10-formyloxy-9-oxo-1,7,13-trihydroxytax-11-ene
• Synonyms: (1S,2S,3R,4S,5R,7S,8S,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-10-formyloxy-9-oxo-1,7,13-trihydroxytax-11-ene
• CAS NO: 184586-78-5
• Molecular Weight: 572.609
• Mol File: 184586-78-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (1S,2S,3R,4S,5R,7S,8S,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-10-formyloxy-9-oxo-1,7,13-trihydroxytax-11-ene(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2S,3R,4S,5R,7S,8S,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-10-formyloxy-9-oxo-1,7,13-trihydroxytax-11-ene(184586-78-5)
• EPA Substance Registry System: (1S,2S,3R,4S,5R,7S,8S,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-10-formyloxy-9-oxo-1,7,13-trihydroxytax-11-ene(184586-78-5)

Safety Data

• Hazardous Substances Data: 184586-78-5(Hazardous Substances Data)

Upstream product

• 32981-86-5 10-deacetylbaccatin III 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 478161-81-8 C₅₄H₇₆N₂O₁₃Si 
• 184586-12-7 C₃₂H₄₀O₉ 
• 184586-77-4 C₂₉H₃₆O₉ 
• 184586-13-8 C₃₂H₄₂O₉ 
• 184586-81-0 (1S,2S,3R,4S,5R,8R,9S,10R,13S)-4-(acetoxy)-2-(benzoyloxy)-5,20-epoxy-1,9,10,13-tetrahydroxytax-11-ene 
• 184586-76-3 C₂₉H₃₄O₉ 
• 184586-80-9 C₃₀H₃₆O₁₀ 
• 272129-02-9 (1S,2S,3R,4S,5R,7S,8R,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-9-oxo-1,10,13-trihydroxytax-6,11-diene 
• 173422-30-5 (1S,2S,3R,4S,5R,7S,8R,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-9-oxo-1,10,13-trihydroxytax-11-ene 
• 184586-79-6 C₃₄H₃₈N₂O₁₁S 
• 478161-64-7 (1S,2S,3R,4S,5R,7S,8S,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-10-formyloxy-1,13-dihydroxy-9-oxo-7-trifluoromethanesulfonyloxytax-11-ene 

Relevant articles and documents

New highly active taxoids from 9β-dihydrobaccatin-9,10-acetals. Part 2

To investigate structure-activity relationships of the 9,10-acetal-9β-dihydro taxoids, we modified the 7-hydroxyl groups of the 9,10-acetonide-3′-(4-pyridyl) analogue to deoxy, methoxy, α-F, and 7β,8β-methano group. As a result of this study, we found that the 7-deoxy analogue was the strongest among these analogues. In addition, we found that the 7-deoxy-3′-(4-pyridyl) and 7-deoxy-3′-(2-pyridyl) analogues showed stronger activity against cell lines expressing P-glycoprotein than the corresponding 3′-phenyl analogue.

A new method for synthesis of 7-deoxytaxane analogues by hydrogenation of Δ6,7-taxane derivatives

A new method for the synthesis of 7-deoxytaxane analogues has been established through hydrogenation of Δ6,7-taxane derivatives. Among several catalysts examined, Pd-C was found to be a most effective catalyst for the preparation of target compound.