478161-81-8

Basic information

• Product Name: C₅₄H₇₆N₂O₁₃Si
• Synonyms: C₅₄H₇₆N₂O₁₃Si
• CAS NO: 478161-81-8
• Molecular Weight: 989.289
• Mol File: 478161-81-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₅₄H₇₆N₂O₁₃Si(CAS DataBase Reference)
• NIST Chemistry Reference: C₅₄H₇₆N₂O₁₃Si(478161-81-8)
• EPA Substance Registry System: C₅₄H₇₆N₂O₁₃Si(478161-81-8)

Safety Data

• Hazardous Substances Data: 478161-81-8(Hazardous Substances Data)

Upstream product

• 478161-64-7 (1S,2S,3R,4S,5R,7S,8S,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-10-formyloxy-1,13-dihydroxy-9-oxo-7-trifluoromethanesulfonyloxytax-11-ene 
• 184586-77-4 C₂₉H₃₆O₉ 
• 184586-76-3 C₂₉H₃₄O₉ 
• 184586-78-5 (1S,2S,3R,4S,5R,7S,8S,10R,13S)-4-acetoxy-2-benzoyloxy-5,20-epoxy-10-formyloxy-9-oxo-1,7,13-trihydroxytax-11-ene 
• 32981-86-5 10-deacetylbaccatin III 
• 184586-12-7 C₃₂H₄₀O₉ 

Relevant articles and documents

New highly active taxoids from 9β-dihydrobaccatin-9,10-acetals. Part 2

To investigate structure-activity relationships of the 9,10-acetal-9β-dihydro taxoids, we modified the 7-hydroxyl groups of the 9,10-acetonide-3′-(4-pyridyl) analogue to deoxy, methoxy, α-F, and 7β,8β-methano group. As a result of this study, we found that the 7-deoxy analogue was the strongest among these analogues. In addition, we found that the 7-deoxy-3′-(4-pyridyl) and 7-deoxy-3′-(2-pyridyl) analogues showed stronger activity against cell lines expressing P-glycoprotein than the corresponding 3′-phenyl analogue.