18714-16-4

Basic information

• Product Name: 2-CYANO-4-PHENYLPYRIDINE
• Synonyms: 4-Phenylpyridine-2-carbonitrile;4-Phenyl-2-pyridinecarbonitrile;2-Pyridinecarbonitrile, 4-phenyl-;4-Phenyl-2-cyanopyridine;4-Phenylpicolinonitrile;2-CYANO-4-PHENYLPYRIDINE
• CAS NO: 18714-16-4
• Molecular Formula: C₁₂H₈N₂
• Molecular Weight: 180.21
• Mol File: 18714-16-4.mol
• Article Data: 16

Chemical Properties

• Melting Point: 97-101 °C
• Boiling Point: 342℃
• Flash Point: 120℃
• Appearance: /
• Density: 1.17
• Vapor Pressure: 7.53E-05mmHg at 25°C
• Refractive Index: 1.62
• CAS DataBase Reference: 2-CYANO-4-PHENYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CYANO-4-PHENYLPYRIDINE(18714-16-4)
• EPA Substance Registry System: 2-CYANO-4-PHENYLPYRIDINE(18714-16-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• Hazardous Substances Data: 18714-16-4(Hazardous Substances Data)

Usage

Purification Methods

Purify the nitrile by recrystallisation from pet ether (m 99-100o). [Case & Gasper J Am Chem Soc 78 5842 1956, Beilstein 22 III/IV 1261.]

InChI:InChI=1/C12H8N2/c13-9-12-8-11(6-7-14-12)10-4-2-1-3-5-10/h1-8H

Upstream product

• 54151-74-5 2-bromo-4-phenylpyridine 
• 1131-61-9 4-Phenylpyridine 1-oxide 
• 7677-24-9 trimethylsilyl cyanide 
• 939-23-1 p-phenylpyridine 
• 79-44-7 N,N-Dimethylcarbamoyl chloride 
• 64-17-5 ethanol 
• 7732-18-5 water 
• 62150-45-2 4-bromo-2-cyanopyridine 
• 98-80-6 phenylboronic acid 
• 773837-37-9 sodium cyanide 
• 591-51-5 phenyllithium 
• 108-86-1 bromobenzene 
• 19235-89-3 4-chloro-pyridine-2-carbonitrile 
• 24388-23-6 2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole 

Downstream Products

• 54824-87-2 6-(4-phenyl-pyridin-2-yl)-[1,3,5]triazine-2,4-diamine 
• 52565-57-8 ethyl 4-phenylpyridine-2-carboxylate 
• 76948-55-5 1,3,5-tris(4-phenyl-2-pyridyl)-2,4,6-triazine 
• 150223-58-8 4-phenylpyridine-2-carbothioamide 
• 209667-83-4 4-Phenyl-pyridine-2-carboximidic acid methyl ester 
• 150223-59-9 4-phenyl-2-<4-(pyridin-2-yl)thiazol-2-yl>pyridine 
• 150223-60-2 4-phenyl-2-<4-(pyridin-2-yl)thiazol-2-yl>pyridine N,N'-dioxide 
• 150223-62-4 C-{6-[4-(6-Aminomethyl-pyridin-2-yl)-thiazol-2-yl]-4-phenyl-pyridin-2-yl}-methylamine 
• 150223-61-3 6-<4-(6-cyanopyridin-2-yl)thiazol-2-yl>-4-phenylpyridine-2-carbonitrile 
• 150223-63-5 di(tert-butyl) 2,2'-<<6-<4-<6-<amino>methyl>pyridin-2-yl>thiazol-2-yl>-4-phenylpyridin-2-yl>methylimino>bis(acetate) 
• 501376-12-1 2-(4-Phenyl-2-pyridyl)-4H-1,3-benzothiazine-4-one 
• 1019927-13-9 1-oxy-4-phenyl-pyridine-2-carbonitrile 
• 106719-06-6 6-chloro-4-phenyl-pyridine-2-carbonitrile 
• 1191264-04-6 4-[(R)-2-[(6-chloro-4-phenyl-pyridine-2-carbonyl)-amino]-3-(diethoxy-phosphoryl)-propionyl]-piperazine-1-carboxylic acid butyl ester 

Relevant articles and documents

1-CYANO-PYRROLIDINE DERIVATIVES AS DUB INHIBITORS

The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase 30 or ubiquitin specific peptidase 30 (USP30). The novel compounds have formula (I): (Formula (I)) or are pharmaceutically acceptable salts thereof, wherein: R1a, R1b, R1c, R1d, R1e and R1f each independently represent hydrogen, optionally substituted C1-C6 alkyl or optionally substituted C3-C4 cycloalkyl, or R1b and R1c together form an optionally substituted C3-C6 cycloalkyl ring, or R1d and R1e together form an optionally substituted C3-C6 cycloalkyl ring; R2 represents hydrogen or optionally substituted C1-C6 alkyl; A represents an optionally further substituted 5 to 10 membered monocyclic or bicyclic heteroaryl, heterocyclyl or aryl ring; L represents a covalent bond or linker; B represents an optionally substituted 3 to 10 membered monocyclic or bicyclic heterocyclyl, heteroaryl, cycloalkyl or aryl ring; and when -A-L-B is at position x attachment to A is via a carbon ring atom of A, and either: A cannot be triazolopyridazinyl, triazolopyridinyl, imidazotriazinyl, imidazopyrazinyl or pyrrolopyrimidinyl; or B cannot be substituted with phenoxyl; or B cannot be cyclopentyl when L is an oxygen atom.

SILICON-BASED CROSS COUPLING AGENTS AND METHODS OF THEIR USE

Compositions and methods using silicon-based cross-coupling agents in the formation of carbon-carbon and carbon-nitrogen bonds are described.

Synthesis of biaryls through a one-pot tandem borylation/Suzuki-Miyaura cross-coupling reaction catalyzed by a palladacycle

The tricyclohexylphosphane adduct of cyclopalladated ferrocenylimine I exhibited high catalytic activity in the one-pot borylation/Suzuki-Miyaura coupling (BSC) reaction with low catalyst loading (2 mol-%). Various biaryls were obtained in good to excellent yields for 37 examples. This process was applied to aryl and heteroaryl halides (Br and Cl) containing a variety of functional groups and did not require an excess amount of phosphane ligand and the addition of the palladium catalyst in the second step. Cyclopalladated ferrocenylimine I exhibited high catalytic activity in the borylation/Suzuki- Miyaura coupling (BSC) reaction with low catalyst loading. Various unsymmetrical biaryls were obtained ingood to excellent yields in one pot. This protocol was applied to aryl and heteroaryl halides (Br and Cl) containing a variety of functional groups without adding catalyst in the second step. Copyright