195136-69-7

Basic information

• Product Name: 2,4-difluoro-1,3-dimethoxybenzene
• Synonyms: 2,4-difluoro-1,3-dimethoxybenzene
• CAS NO: 195136-69-7
• Molecular Weight: 174.147
• Mol File: 195136-69-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 230.2±35.0 °C(Predicted)
• Density: 1.193±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2,4-difluoro-1,3-dimethoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-difluoro-1,3-dimethoxybenzene(195136-69-7)
• EPA Substance Registry System: 2,4-difluoro-1,3-dimethoxybenzene(195136-69-7)

Safety Data

• Hazardous Substances Data: 195136-69-7(Hazardous Substances Data)

Upstream product

• 551-62-2 1,2,3,4-tetrafluorobenzene 
• 6303-21-5 hypophosphorous acid 
• 195136-67-5 1-amino-3,5-difluoro-2,4-dimethoxybenzene 
• 195136-63-1 1,3-difluoro-2,4-dimethoxy-5-nitrobenzene 
• 5580-79-0 2,3,4,5-tetrafluoro-1-nitrobenzene 

Downstream Products

• 215868-23-8 6,8-difluoro-7-hydroxy-4-methyl-2H-chromen-2-one 
• 215868-26-1 6',8'-difluoro-4’-methylumbelliferyl α-D-glucopyranoside 
• 215868-31-8 6,8-difluoro-7-hydroxycoumarin-3-carboxylic acid 
• 209541-27-5 3,5-Difluoro-2,4-dihydroxybenzaldehyde 
• 1581248-41-0 2′,4′,5′,7′-tetrafluoro-3′,6′-dihydroxy-5,10-diphenyl-3H-spiro-[anthra[2,3-c]furan-1,9′-xanthen]-3-one 
• 195136-71-1 2,4-difluorobenzene-1,3-diol 

Relevant articles and documents

FLUORINATED 4' ALKYLUMBELLIFERYL α-D-GLUCOPYRANOSIDES, BIOLOGICAL STERILIZATION INDICATORS INCLUDING THE SAME AND METHODS OF USING THE SAME

A self-contained biological sterilization indicator comprises: a housing; bacterial spores comprising, and/or capable of producing, an enzyme capable of catalyzing cleavage of an enzyme substrate; and a frangible container containing a composition, wherein the composition comprises the enzyme substrate, wherein if the frangible container is broken the composition will contact the bacterial spores to form a mixture having an initial pH in the range from 6.0 to 9.0. The enzyme substrate comprises a fluorinated 4'-alkylumbelliferyl α-D-glucopyranoside represented by the structural formula (I) wherein one of R1 and R2 is F and the other is H, and R3 is an alkyl group having from 1 to 12 carbon atoms. A biological sterilization indicator comprising a kit containing isolated components comprising (i) bacterial spores comprising, and/or capable of producing, an enzyme capable of catalyzing cleavage of the enzyme substrate and a method of assessing efficacy of a sterilization process are also disclosed.

Aarhus sensor green: A fluorescent probe for singlet oxygen

A tetrafluoro-substituted fluorescein derivative covalently linked to a 9,10-diphenyl anthracene moiety has been synthesized, and its photophysical properties have been characterized. This compound, denoted Aarhus Sensor Green (ASG), has distinct advantages for use as a fluorescent probe for singlet molecular oxygen, O2(a1δg). In the least, ASG overcomes several limitations inherent to the use of the related commercially available product called Singlet Oxygen Sensor Green (SOSG). The functional behavior of both ASG and SOSG derives from the fact that these weakly fluorescent compounds rapidly react with singlet oxygen via a π2 + π4 cycloaddition to irreversibly yield a highly fluorescent endoperoxide. The principal advantage of ASG over SOSG is that, at physiological pH values, both ASG and the ASG endoperoxide (ASG-EP) do not themselves photosensitize the production of singlet oxygen. As such, ASG better fits the requirement of being a benign probe. Although ASG readily enters a mammalian cell (i.e., HeLa) and responds to the presence of intracellular singlet oxygen, its behavior in this arguably complicated environment requires further investigation.

Fluorinated xanthene derivatives

The family of dyes of the invention are fluoresceins and rhodols that are directly substituted on one or more aromatic carbons by fluorine. These fluorine-substituted fluorescent dyes possess greater photostability and have lower sensitivity to pH changes in the physiological range of 6-8 than do non-fluorinated dyes, exhibit less quenching when conjugated to a substance, and possess additional advantages. The dyes of the invention are useful as detectable tracers and for preparing conjugates of organic and inorganic substances.