198020-19-8Relevant articles and documents
Facile Synthesis of Potent HIV-1 Protease Inhibitors containing a Novel Pseudo-symmetric Dipeptide Isostere
Sham, Hing L.,Betebenner, David A.,Zhao, Chen,Wideburg, Norman E.,Saldivar, Ayda,et al.
, p. 1052 - 1053 (1993)
A series of potent inhibitors of the HIV-1 protease containing a novel pseudo-symmetric dipeptide isostere 3 was synthesized via ring opening of a protected epoxide with various substituted hydrazines.
Antiviral drug and its pharmaceutical composition
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Paragraph 0203-0204, (2017/03/21)
The invention relates to an antiviral medicine and a medicine composition thereof, in particular relates to an anti-human immunodeficiency virus (HIV) medicine and a medicine composition thereof, and especially relates to a medicine which can be taken as
Process for producing 3-amino-2-oxo-1-halogenopropane derivatives
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, (2008/06/13)
Compounds formed by reacting a protected amino acid with an alkali metal enolate of an alkyl acetate are reacted with a halogenating agent for halogenation of the 2-position, or a protected amino acid is reacted with an alkali metal enolate of an alkyl halogenoacetate, to form a 4-amino-3-oxo-2-halogenobutanoic acid ester derivative, and hydrolysis and decarboxylation are conducted to produce a 3-amino-2-oxo-1-halogenopropane derivative or its salt. The present method is a useful process for producing a 3-amino-2-oxo-1-halogenopropane derivatives which can easily be converted to a 3-amino-1,2-epoxypropane.