143601-45-0Relevant articles and documents
A SIMPLE SYNTHETIC APPROACH TO Cbz-Phe-Ψ-(CH2)Gly-Pro-OMe AND RELATED PEPTIDE ISOSTERES
Hoffman, Robert V.,Kim, Hwa-Ok
, p. 3579 - 3582 (1992)
A new approach to ketomethylene and hydroxymethylene peptide isosteres has been developed which is simple, direct, and highly convergent.A key feature is construction of the central bond of a γ-keto ester by alkylation of a t-butyl β-keto ester with an α-bromo ester.
An efficient synthesis of γ-amino β-ketoester by cross-Claisen condensation with α-amino acid derivatives
Honda, Yutaka,Katayama, Satoshi,Kojima, Mitsuhiko,Suzuki, Takayuki,Izawa, Kunisuke
, p. 3163 - 3166 (2007/10/03)
Cross-ester condensation between N-protected amino acid ester and the lithium enolate prepared from alkyl acetate gave the corresponding β-ketoester in high yield without the formation of the tertiary alcohol that is commonly seen as by-product. This inte
Process for producing 3-amino-2-oxo-1-halogenopropane derivatives
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, (2008/06/13)
Compounds formed by reacting a protected amino acid with an alkali metal enolate of an alkyl acetate are reacted with a halogenating agent for halogenation of the 2-position, or a protected amino acid is reacted with an alkali metal enolate of an alkyl halogenoacetate, to form a 4-amino-3-oxo-2-halogenobutanoic acid ester derivative, and hydrolysis and decarboxylation are conducted to produce a 3-amino-2-oxo-1-halogenopropane derivative or its salt. The present method is a useful process for producing a 3-amino-2-oxo-1-halogenopropane derivatives which can easily be converted to a 3-amino-1,2-epoxypropane.